Abstract: Objective To investigate the influencing factors of nonalcoholic steatohepatitis (NASH) progression to cirrhosis in order to prevent the development of NASH-related cirrhosis (NASLC) at an early stage. Methods A case-control study was conducted in patients enrolled from Mengchao Hepatobiliary Hospital of Fujian Medical University between December 2017 and December 2019. Within them, 45 hospitalized patients with NASH-related cirrhosis were selected as the case group, and 180 age- and sex-matched NASH patients without cirrhosis that were admitted during the same period of time was selected as the control group. The study aimed to analyze the risk factors associated with NASLC. Results In the case group, the levels of prothrombin time (PT), prothrombin time and international normalised ratio (PT-INR), thrombin time (TT), and total bilirubin (TBil) were (13.98±3.88)s, 1.01(0.92,1.10), (17.57±1.57)s, and 17.5(9.4,26.5)μmol/L, respectively, which were significantly higher than those of (12.91±2.16)s, 0.95(0.88,1.03), (16.99±1.69)s and 14.1(6.3,21.0)μmol/L in the control group. Conversely, the prothrombin time activity (PTA), uric acid (UA), total glycerol (TG) platelet count (PLT) and white blood cells count (WBC) in the case group were (95.62±18.78)% (286.84±84.77)μmol/L, 1.54(0.95,2.20)mmol/L, (5.56±2.12)×10⁹/L, and (167.71±70.24)×10⁹/L, respectively, which were significantly lower than those of (105.78 ± 15.17)%, (342.57 ± 108.37) μmol/L, 1.91(1.20,2.7) mmol/L, (6.97±3.87)× 10⁹/L, and (232.06±81.61)×10⁹/L in the control group (all P<0.05). By multifactorial logistic regression analysis it was revealed that the variables associated with NASH-related cirrhosis risk with statistical significance were UA (OR=0.994, 95% CI: 0.990~0.998) and PLT (OR=0.989, 95%CI: 0.984~0.994). Conclusion Decreased UA and PLT are independent risk factors for NASLC.

Key words: Non-alcoholic steatohepatitis, Non-alcoholic steatohepatitis-related cirrhosis, Risk factors, UA, PLT