Follow-up analysis of clinical efficacy and safety of patients with hepatitis C cirrhosis receiving different DAAs

Abstract

Abstract: Objective To compare the clinical data of patients with chronic hepatitis C cirrhosis (CHCC) treated with different direct-acting antiviral agents (DAAs), and evaluate their efficacy and safety. Methods 114 patients with CHCC admitted to the Second Affiliated Hospital of Air Force Medical University from January 2022 to June 2024 were included. The DAAs regimens adopted included sofebuvir combined with ribavirin (SOF group), sofebuvir, ledepavir combined with ribavirin (SOF+LDV group) and sofebuvir and daclatasir combined with ribavirin (SOF+DCV group). The therapeutic effects, blood biochemical parameters before and after treatment, and adverse reactions of each group were compared. Results In the SOF+LDV group and the SOF+DCV group, the early virological response, end-of-treatment virological response and sustained virology response were all 100%, significantly higher than those in the SOF group (37.5%, 33.3%, and 31.2%, respectively; P<0.05). Compared with the SOF group [(1.7±0.5) lg IU/mL, (38.5±4.4) U/L, (37.2±4.3) U/L, and (13.2±2.3) kPa], the SOF+LDV group [(1.2±0.4) lg IU/mL, (32.4±4.7) U/L, (32.0±4.9) U/L, and (11.0±2.8) kPa] and the SOF+DCV group [(1.1±0.6) lg IU/mL, (31.7±5.0) U/L, (32.7±6.1) U/L, and (10.4±3.0) kPa] showed statistically significant differences (P<0.05). All adverse events occurred within 2 weeks of treatment and resolved spontaneously. No statistically significant difference was observed in the incidence of adverse events among the groups (χ²=0.349, P>0.05). Conclusion SOF+LDV and SOF+DCV have higher virological response rate and more significant improvement of liver function in patients with CHCC, and their safety is good. The research results provide an important basis for the application of DAAs in patients with CHCC, and provide a reference for the selection of treatment schemes in clinical practice.

Key words: Chronic hepatitis C cirrhosis, Direct-acting antiviral agents, Sustained virological response, Sofosbuvir

Li Man, Wang Rui, Wang Miaomiao, Wang Chunfu, Du Qian. Follow-up analysis of clinical efficacy and safety of patients with hepatitis C cirrhosis receiving different DAAs[J]. Chinese Hepatolgy, 2026, 31(7): 958-961.

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