Abstract: Objective To investigate the prognostic factors for patients with hepatic myelopathy (HM) and its risk factors.Methods In this retrospective cohort study, clinical data of 91 cases with HM admitted in our hospital from January 2006 to April 2015 was collected. The patients were divided into improved group (n=12) and deteriorated group (n=79). The correlation between prognosis and clinical features, which including age, sex, duration of liver disease, Child-Pugh score, drinking alcohol hobby, history of splenectomy, history of transjugular intrahepatic portosystemic shunt, complications of liver cirrhosis, comorbidies, laboratory indicators and so on, were analyzed by univariate analysis and further investigated by logistic regression analysis.Results Univariate analysis revealed that prothrombin activity (PTA), cholinesterase (CHE) and Child-Pugh score were important factors affecting the prognosis (P<0.05). Compared with the improvement group, the deterioration group showed lower levels of PTA and CHE, higher Child-Pugh score (P<0.05). Furthermore, logistic regression analysis indicated that low level of CHE and high Child-Pugh score had statistically significant correlation with poor prognosis of HM patients (P<0.05), with odds ratio as 0.243 and 32.825 respectively.Conclusion CHE and Child-Pugh score are independent risk factors for prognosis of HM patients. For those patients, low level of CHE and high rank of Child-Pugh class predicts poor prognosis.

Key words: Hepatic myelopathy, Prognosis, Logistic regression analysis