Abstract: Objective To investigate the clinical value of the model for end-stage liver disease (MELD) and the sequential organ failure assessment (SOFA) scoring systems in predicting short-term prognosis of patients with acute-on-chronic liver failure (ACLF).Methods Seven-eight ACLF patients were divided into survival group and death group according to their 3-month living conditions. MELD and SOFA score were calculated among those patients. Receiver operating characteristic curve (ROC) was applied to evaluate the predictive value, and differences between two models were analyzed by K-M survival curve.Results MELD and SOFA scoring systems could well predict the mortality of ACLF patients in 3 months with C-statistics of 0.826 and 0.825, respectively, which showed no significant differences (Z=0.0148, P=0.988). Compared with patients with SOFA score ≥ 7 points and MELD score ≥ 23.9 points, patients with SOFA score < 7 points and MELD score < 23.9 points had significantly higher survival rate, respectively (χ²=17.66 and 28.33, both P=0.000).Conclusion Efficiencies of MELD and SOFA scoring systems shows no significant difference in predicting the short-term prognosis of ACLF patients.

Key words: MELD, SOFA, Acute-on-chronic liver failure, Prognosis