Abstract: Objective To investigate the etiology and clinical characteristics of patients with abnormal liver function, and to assess the spectrum of liver dysfunctions at present.Methods Data of in-patients diagnosed of abnormal liver function from January 2010 to May 2015 in our department was retrospectively analyzed.Results Among 2510 cases with abnormal liver function during the past 5 years, certain causes could only be found in 925 cases (36.85%) involving 19 kinds of diseases. Furthermore, viral hepatitis (17.65%, 443/2510), drug-induced liver injury (7.81%, 196/2510), biliary hepatitis (3.75%, 94/2510) and autoimmune liver diseases (3.23%, 81/2510) ranked the top 4 in those with clear diagnosis.Conclusion More than half cases (63.15%) with abnormal liver function were very difficult to be exactly diagnosed. In addition, drug-induced liver injury, biliary hepatitis and autoimmune liver disease could not be ignored besides viral hepatitis.

Key words: Abnormal liver function test, Etiology, Clinical characteristic