Abstract: Objective To explore the factors influencing poor response on treatment of autoimmune hepatitis (AIH). Methods The clinical data of 78 patients with AIH admitted to our hospital from January 2012 to October 2019 were analyzed retrospectively. All patients were divided into good response group (n = 54) and poor response group (n = 24) according to the response after treatment.To compare the differences between the two groups in basic data (gender, age), clinical symptoms (whether there is fatigue, nausea, jaundice, poor appetite, abdominal pain), serum indexes (ANA, AMA, alt, AST, TBIL, ALP), we will find that there are different information lines and using multi factor logistic. C regression analysis to explore the risk factors of poor response after AIH treatment. Results Patients with fatigue, nausea and jaundice in the poor response group accounted for 75.00%, 79.16%, 83.33%, 79.17% and 75.00% of those with positive ANA and AMA antibodies, which were significantly higher than those in the good response group (25.00%, 20.83%, 16.67%, 20.83% and 25.00%, all P<0.05).The results of multivariate logistic regression analysis showed that patients with AIH had symptoms of asthenia, nausea and jaundice. The high expression of ALP was a risk factor for poor response after treatment, all of which were P<0.05. Conclusion Patients with poor response to AIH often have symptoms of asthenia, nausea and jaundice, and ALP in serum shows high expression, which are risk factors for poor response on treatment.

Key words: Autoimmune hepatitis, Poor response, Clinical characteristics, Risk factors