Analysis of gender disparity of viral markers and liver function indicators in chronic hepatitis B patients

Abstract

Abstract: Objective To clarify the sex disparity of chronic hepatitis B in seum viral markers and liver function parameters.Methods Clinical informations from 155 chronic hepatitis B (CHB) patients were analyzed in this retrospective study. HBeAg or HBeAb, HBsAb, HBcAb and HBV DNA in different genders were compared between the cases with and those without HBeAg seroconversion. The relationship between HBsAg levels and liver injury Indicators including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glutamyl transpeptidase (GGT), and other serological markers such as total bilirubin (TB), albumin (ALB), globin (GLB), prothrombin time (PT), international normalized ratio (INR) and platelet count (PLT). Results In HBeAg-negative patients, the serum levels of HBsAg and HBV DNA in males were significantly higher than in females. When analysis the correlation of these clinical indicators with HBsAg, it was found that HBsAg positively correlated with HBV DNA in males and in HBeAg positive females. In addition, there are a negative correlation between HBsAg and TB, PT or AST in HBeAg positive males.Conclusion Gender disparity is not only presented in viral markers, but also in other serological indicators in CHB patients.

Key words: Chronic hepatitis B, Gender disparity, Liver function, HBsAg

FANG Zhong, WANG Cong, HUANG Yu-xian, CHEN Liang, ZHANG Yi. Analysis of gender disparity of viral markers and liver function indicators in chronic hepatitis B patients[J]. Chinese Hepatolgy, 2021, 26(2): 128-130.

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