The correlation between CYP2E1 and CYP1A1 genotypes with the susceptibility of HBV infection in northern Guangzhou people

Abstract

Abstract: Objective To analyze the association between CYP2E1 and CYP1A1 genotypes with the susceptibility of HBV infection in northern Guangzhou people.Methods 150 patients with HBV infection were enrolled as the experimental group and 150 healthy cases were selected as the control group. The polymorphisms of rs3813867 and rs2031920 in CYP2E1 gene, and rs4646421 and rs2198843 in CYP1A1 gene were detected in all people by snapshot. The frequencies of the distributions of the genotypes were compared between these two groups. Clinical data of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamyl transpeptidase (GGT), total bilirubin (T-Bil), alpha fetoprotein (AFP) and HBV DNA were collected and analyzed for their relationship with significance mutation genotypes. Results Hardy-Weinberg equilibrium was found in both groups (P>0.05).The frequencies of rs4646421 and rs2198843 genotypes of CYP1A1 gene in experimental group were not significantly different between two groups (P>0.05), the frequencies of rs3813867 and rs4646421 genotypes of CYPE1 gene in experimental group were significantly different between two groups (P<0.05); At rs3813867 locus, the risk of hepatitis in individuals with CC genotype was 5.59 times higher than those with GG genotype. At rs2031920 locus, the risk of developing hepatitis in individuals with TT genotype was 3.57 times higher than those with CC genotype,but the frequencies of rs3813867 and rs4646421 genotypes in CYPE1 gene had no significant difference among all clinical indicators (all P>0.05).Conclusion Rs3813867 and rs4646421 of CYPE1 gene but not rs4646421 and rs2198843 in CYP1A1 gene were associated with the susceptibility of HBV infection in northern Guangzhou people.

Key words: rs3813867, rs2031920, rs4646421, rs2198843, Genotype, HBV

HONG Xiao-lv, XU Pei-yan, PAN Xiao-ping. The correlation between CYP2E1 and CYP1A1 genotypes with the susceptibility of HBV infection in northern Guangzhou people[J]. Chinese Hepatolgy, 2021, 26(2): 131-135.

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