The value of gadolinium diamine enhanced MRI and enhanced CT in the diagnosis of hepatocellular carcinoma in Child-Pugh grade A patients

Abstract

Abstract: Objective To investigate the clinical value of gadolinium diamine enhanced magnetic resonance imaging (MRI) and enhanced computed tomography (CT) in the diagnosis of hepatocellular carcinoma (HCC) in Child-Pugh grade A patients. Methods A total of 114 Child-Pugh grade A patients with HCC admitted to our hospital from December 2018 to December 2020 were selected. All patients underwent gadolinium diamine enhanced MRI and enhanced CT. The detection rate of nodules, enhancement methods and detection rate of capsule between the 2 imaging methods were compared. Results All of the 114 patients were confirmed by pathology, and 150 HCC nodules were found. The sensitivity of gadolinium diamine enhanced MRI in detection of HCC nodules was 94.67%, which was significantly higher than that of enhanced CT (81.33%), (P<0.05). The detection rates of gadolinium diamine enhanced MRI in multiple nodules and HCC nodules <20 mm were 76.76% and 42.25%, respectively, which were significantly better than those of enhanced CT (44.26% and 23.77%), (P<0.05). Gadolinium diamine enhanced MRI and enhanced CT showed a trend of low signal/low density along with time when scanning HCC lesions. All HCC tumor lesions scanned by MRI showed low signals in hepatobiliary phase, with a detection rate of 100%. Ninety tumor nodules with capsules were found in 114 HCC patients, which were confirmed by pathology. The sensitivity of detecting the capsules of HCC nodules through gadolinium diamine enhanced MRI was 85.56%, which was significantly higher than that of enhanced CT 50.00% (P<0.05). There was no significant difference between the 2 imaging methods in observing the features of capsules surround HCC (P>0.05). Conclusion Gadolinium diamine enhanced MRI performs better than enhanced CT in detecting HCC nodules and tumor capsules. Gadolinium diamine enhanced MRI also performs better in showing enhancement characteristics of HCC, which has a higher diagnostic value for hepatobiliary specific phase HCC.

Key words: Gadolinium diamine, Magnetic resonance imaging, Computed tomography, Hepatocellular carcinoma

GUO Da-ke, LIU Bing, LIU Bin. The value of gadolinium diamine enhanced MRI and enhanced CT in the diagnosis of hepatocellular carcinoma in Child-Pugh grade A patients[J]. Chinese Hepatolgy, 2021, 26(11): 1264-1267.

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