Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (11): 1268-1271.

• Liver Cancer • Previous Articles     Next Articles

The value of blood supply observed through CTPI in evaluating the prognosis of patients with primary liver cancer after TACE

LI Zhen-zhen1, GENG Yun-ping1, REN You-you1, YOU Guo-qing1, ZENG Qing2   

  1. 1. Department of CT Imaging, Nanyang Central Hospital, Henan 473000, China;
    2. Department of interventional radiology, Nanyang Central Hospital, Henan 473000, China
  • Received:2020-12-20 Online:2021-11-30 Published:2021-12-24
  • Contact: LI Zhen-zhen,Email:h156954@126.com

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Abstract: Objective To investigate the value of blood supply state in evaluating the prognosis of patients with primary liver cancer after transcatheter arterial chemoembolization (TACE) by computed tomography perfusion imaging (CTPI). Methods A total of 257 patients with primary liver cancer who underwent TACE from March 2014 to November 2019 were included in the study. The parameters of the hepatic blood flow (HBF), hepatic artery perfusion index (HPI), time to peak (TTP) and hepatic artery perfusion volume (HAP) were recorded before and after TACE through CTPI. The levels of vascular endothelial growth factor (VEGF) and microvessel density (MVD) were detected by histopathological biopsy before TACE. The correlations between VEGF, MVD and CT perfusion parameters were analyzed. The therapeutic effects were recorded and the levels of HBF, HPI, TTP and HAP of patients with different effects were compared. The value of CTPI parameters in evaluating the short-term prognosis of patients after TACE was analyzed. Results Three months after TACE, 38 patients got complete remission (CR), 128 patients got partial remission (PR), 36 patients got stable disease (SD) and 55 patients got progressive disease (PD). The Pearson linear correlation analysis showed that VEGF and MVD were positively correlated with HBF, HPI and HAP, and negatively correlated with TTP (P<0.05). The receiver operating characteristic (ROC) curve showed that the HBF, HPI, HAP and TTP were helpful to evaluated the therapeutic effect of TACE (P<0.05). The efficacy index model of Y=X1+X2+X3+X4 (HBF: X1, HPI: X2, HAP: X3, TTP: X4) was established according to the results of ROC analysis, the area under curve (AUC) of short-term efficacy was 0.870 (AUC = 0.870, S.E. = 0.025, 95%CI = 0.821-0.919, P=0.000). Conclusion CTPI can be used to evaluate the blood supply of patients with primary liver cancer before and after TACE treatment, and judge the short-term prognosis.

Key words: Computed tomography perfusion imaging, Primary liver cancer, Transcatheter arterial chemoembolization, Prognosis