Relationship between serum miR-15b-5p and miR-145 and poor prognosis after TACE treatment in patients with primary liver cancer

Abstract

Abstract: Objective To investigate the correlation between serum microRNA (miR) -145 and miR-15b-5p and the prognosis of patients with primary liver cancer after transcatheter arterial chemoembolization (TACE).Methods A total of 129 patients with primary liver cancer admitted to Qidong People's Hospital from March 2020 to April 2022 were selected. According to their 3-month postoperative prognosis, the patients were divided into good prognosis group and bad prognosis group. The study aimed to analyze the influencing factors of poor prognosis in patients with primary liver cancer and the predictive value of miR-145, miR-15b-5p and their combination in predicting the poor prognosis of primary liver cancer.The patients were followed up for 2 years and their survival was recorded.Results The proportion of portal vein cancer thrombus, incomplete capsule and continuous tumor margin in poor prognosis group was higher than good prognosis group (P<0.05). The miR-15b-5p and neutrophil to lymphocyte ratio (NLR) in the poor prognosis group were higher than good prognosis group, but lower in the poor prognosis group (P<0.05). Envelope integrity, serum miR-145, tumor margin, and serum miR-15b-5p were the influencing factors for poor prognosis of patients with primary liver cancer (P<0.05).The area under the curve (AUC) of serum miR-145, serum miR-15b-5p, and a combination of serum miR-145 and serum miR-15b-5p in predicting poor prognosis of patients with primary liver cancer were 0.815, 0.805 and 0.902, respectively (P<0.05). The survival rate of patients with low serum miR-15b-5p level was lower than patients with high serum miR-15b-5p level (P<0.05), and the survival rate of patients with high serum miR-145 level was higher than patients with low serum miR-145 level (37.21%) (P<0.05). Serum miR-145 was negatively correlated with miR-15b-5p (P<0.05).Conclusion The combination of serum miR-15b-5p and miR-145 levels has a higher value in predicting the prognosis of liver cancer after TACE.

Key words: Primary liver cancer, Microrna-15b-5p, Microrna-145, Transcatheter hepatic arterial chemoembolization, Poor prognosis, Predictive value

ZHANG Zi-qiang, CHEN Kai-rong, WU Jun, LIU Jin-long, MA Feng. Relationship between serum miR-15b-5p and miR-145 and poor prognosis after TACE treatment in patients with primary liver cancer[J]. Chinese Hepatolgy, 2024, 29(12): 1503-1507.

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