Clinical manifestations and histopathological features of 30 patients with perivascular epithelioid cell tumors of the liver

Abstract

Abstract: Objective To analyze the clinical manifestations and histopathological features of 30 patients with perivascular epithelioid cell tumors of the liver.Methods Thirty patients with surgically resected and pathologically confirmed hepatic perivascular epithelioid cell tumors admitted to the 909th Hospital of the Joint Support Force between February 2019 and February 2020 were collected for clinical data and analyzed with clinical manifestations and histopathological features.Results Among the 30 cases, there were 10 males and 20 females. The age of onset was mostly 25~54 years old, and most of them had epigastric pain symptoms. The tumors were mostly solitary, the lesions were mostly located in the left outer lobe of the liver, and the tumors were between 60~100 mm. The liver function tests showed elevated levels of serum glutamate transaminase, alkaline phosphatase and bilirubin, and immunohistochemistry was mainly positive for anti-melanoma-specific monoclonal antibody, melanocyte antigen and anti-smooth muscle antibody. Among the 30 cases, 27 cases were available for follow-up within 2 years after surgery, and 3 cases received only 1 year of follow-up, with a follow-up rate of 90.0%. 27 cases were not found to have tumor metastasis or recurrence during the follow-up period, and no other treatment was performed after surgery, and the patients were in good condition until February 2022, and most of the liver CT, blood routine, and liver function tests were not abnormal.Conclusion Perivascular epithelial cell tumor of the liver is a very rare interstitial tumor that is easily confused with other liver tumors. Combining clinical and pathological features, the application of CT imaging, abdominal ultrasound, and MRI imaging can provide reliable basis for the diagnosis and differential diagnosis of perivascular epithelial cell tumors of the liver.

Key words: Perivascular epithelioid cell tumor of the liver, Clinical manifestations, Histopathology

WEN Lu-sheng, GENG Yue-hua, LIU Jin-fa, ZHOU Xiao-qin. Clinical manifestations and histopathological features of 30 patients with perivascular epithelioid cell tumors of the liver[J]. Chinese Hepatolgy, 2024, 29(12): 1508-1511.

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