Chinese Hepatolgy ›› 2025, Vol. 30 ›› Issue (12): 1706-1709.

• Metabolic Associated Fatty Liver Disease • Previous Articles     Next Articles

Changes of peripheral blood lymphocyte and CD4+T cell subsets in patients with nonalcoholic fatty liver disease and psoriatic arthritis and their relationship with dyslipidemia

SHEN Yan, ZHANG Li, ZHOU Hui-min   

  1. Department of Blood Transfusion, Xuzhou Central Hospital, Xuzhou 221000, China
  • Received:2025-01-20 Published:2026-02-10
  • Contact: ZHOU Hui-min,Email:z19952199290@163.com

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Abstract: Objective To analyze the changes of peripheral blood lymphocyte subsets and blood lipid levels in patients with nonalcoholic fatty liver disease (NAFLD) complicated with psoriasis, and to analyze their influence on the occurrence of psoriatic arthritis (PA). Methods Between February 2020 and February 2024, 105 patients with NAFLD complicated with psoriasis in our hospital were divided into non-PA group and PA group according to whether they were complicated with PA. The general data, lymphocyte subsets and blood biochemical indexes, of the two groups were compared, and the factors affecting PA in NAFLD complicated with psoriasis were analyzed by multivariate logistic regression. Results Among 105 patients with NAFLD complicated with psoriasis, 14 patients were complicated with PA (PA group). The scores of BMI, diabetes, FBG, HbA1C, hyperlipidemia, metabolic syndrome, fatty liver, lesion area and lesion severity in patients with non-PA group were 24.0 kg/m2, 28 cases (30.8%), 6.5 mmol/L, 6.1%, 43 cases (47.2%), 37 cases (40.6%), 33 cases (36.3%), 4.7 points and 3.5 points, compared with PA group [25.4 kg/m2, 9 cases (64.3%), 7.7 mmol/L, 6.9%, 12 cases (85.7%), 11 cases (40.7%) , 10 cases (71.4%), 6.7points and 4.5points], the difference was statistically significant (P<0.05). The percentage of CD4+ cells and CD4+/CD8+ cells in peripheral blood of patients with non-PA were 35.4 % and 1.3,), which were significantly higher than those of patients with PA (32.7% and 1.1, P<0.05). Substituting these differences into multivariate analysis, hyperlipidemia, metabolic syndrome, fatty liver and CD4+/CD8+ are independent risk factors for PA in patients with NAFLD complicated with psoriasis (P<0.05), while HDL is a protective factor (P<0.05). Conclusion The occurrence of PA is influenced by multiple factors, and the existence of NAFLD may increase the risk of PA in psoriasis by promoting inflammatory response and immune disorder. The changes of blood lymphocyte subsets and blood lipid indexes further reveal the complex interaction between metabolism and immune system. Hyperlipidemia, metabolic syndrome, fatty liver and LDL are independent risk factors for PA in patients with NAFLD complicated with psoriasis, while HDL is a protective factor.

Key words: Nonalcoholic fatty liver disease, Psoriatic arthritis, Peripheral blood lymphocyte subsets, CD4+ T cell subsets, Dyslipidemia