[1] Lee WM. Drug-induced acute liver failure. Clin Liver Dis, 2013, 17:575-586. [2] Jaeschke H, Xie Y, McGill MR. Acetaminophen-induced Liver Injury: from Animal Models to Humans. J Clin Transl Hepatol, 2014, 2:153-161. [3] Maes M, Vinken M, Jaeschke H. Experimental models of hepatotoxicity related to acute liver failure. Toxicol Appl Pharmacol, 2016, 290:86-97. [4] Jaeschke H. Acetaminophen: Dose-dependent drug hepatotoxicity and acute liver failure in patients. Dig Dis, 2015, 33:464-471. [5] Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol, 2016, 16:407-420. [6] Szabo G, Petrasek J. Inflammasome activation and function in liver disease. Nat Rev Gastroenterol Hepatol, 2015, 12: 387-400. [7] Vince JE, Silke J. The intersection of cell death and inflammasome activation. Cell Mol Life Sci, 2016, 73: 2349-2367. [8] Cullen SP, Kearney CJ, Clancy DM. Martin Diverse activators of the NLRP3 inflammasome promote IL-1beta secretion by triggering necrosis. Cell Rep, 2015, 11: 1535-1548. [9] Levinsohn JL, Newman ZL, Hellmich KA, et al. Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. PLoS Pathog, 2012, 8 e1002638. [10] Huebener P, Pradere JP, Hernandez C, et al. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification fol-lowing necrosis. J Clin Invest, 2015, 125: 539-550. [11] Possamai LA, McPhail MJ, Khamri W, et al. The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity. Liver Int, 2015, 35:764-773. [12] Manakkat Vijay GK, Ryan JM, Abeles RD, et al. Neutrophil toll-like receptor 9 expression and the systemic inflammatory response in acetaminophen-induced acute liver failure. Crit Care Med, 2016, 44:43-53. [13] Taylor NJ, Nishtala A, Manakkat Vijay GK, et al. Circulating neutrophil dysfunction in acute liver failure. Hepatology, 2013, 57:1142-1152. [14] Marques PE, Oliveira AG, Pereira RV, et al. Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice. Hepatology, 2015, 61:348-360. [15] Antoniades CG, Khamri W, Abeles RD, et al. Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure. Hepatology, 2014, 59:1564-1576. |