肝细胞癌中FHIT、P16和MMP-9的表达和意义

肝脏 ›› 2019, Vol. 24 ›› Issue (10): 1170-1171.

肝细胞癌中FHIT、P16和MMP-9的表达和意义

夏振雄, 周程

430022 湖北武汉武汉市第一医院肝胆外科

收稿日期:2019-02-27 发布日期:2020-03-27
通讯作者: 周程
基金资助:
湖北省自然科学基金(2014CFC1042)

Received:2019-02-27 Published:2020-03-27

摘要/Abstract

摘要： 目的研究脆性组氨酸三联体(FHIT)、P16和基质金属蛋白酶-9(MMP-9)在肝细胞癌组织中的表达及其临床病理学意义。方法采用免疫组化SP法分别检测90例肝细胞癌组织和40例癌旁组织中FHIT、P16和MMP-9蛋白的表达。结合临床病例资料,分析FHIT、P16和MMP-9表达与年龄、性别、肿瘤大小、TNM分期、分化程度、淋巴结转移以及门静脉癌栓形成之间的关系。结果 FHIT和P16蛋白在肝细胞癌组织中阳性表达率分别为36.7%(33/90)和38.9%(35/90),均显著低于癌旁组织(P<0.05);MMP-9阳性率为75.6%(68/90),显著高于癌旁组织(P<0.05)。FHIT的表达与肝细胞癌的分化程度、淋巴结转移情况以及门静脉癌栓是否形成有关(P<0.05);P16与肿瘤大小和分化程度有关(P<0.05);MMP-9与淋巴结转移情况和门静脉癌栓是否形成有关(P<0.05)。结论 FHIT、P16和MMP-9蛋白在肝细胞癌中表达异常,临床检测3种蛋白的表达有可能成为肝细胞癌临床检测新的指标。

关键词: 肝细胞癌, 脆性组氨酸三联体, P16, 基质金属蛋白酶-9

夏振雄, 周程. 肝细胞癌中FHIT、P16和MMP-9的表达和意义[J]. 肝脏, 2019, 24(10): 1170-1171.

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