关键词: 超声心动图, 肝硬化, 左心室 , 应变, 三维

Abstract: Objective To evaluate myocardial mechanics of left ventricle in patients with early-stage liver cirrhosis using three-dimensional echocardiographic strain parameters, and to explore effective ultrasonic parameters for diagnosis of cirrhotic cardiomyopathy.Methods Twenty-eight healthy volunteer were enrolled as controls (group A), and 25 early-stage cirrhotic patients were enrolled in group B. Three-dimensional speckle tracking imaging (3D-STI) were applied to analyze global 3-D strain (G3DS), global longitudinal strain (GLS) and area strain dyssynchrony index (ASDI) of left ventricle. Meanwhile, left ventricular ejection fraction (LVEF),left ventricular end-diastolic volume (LVEDV) and early diastolic wave/atrial contractive wave (E/A) ratio of mitral flow were measured using conventional ultrasound. Results Compared with those in group A, G3DS, GLS and E/A ratio in group B were significantly decreased (P<0.05), while ASDI was significantly increased (P<0.05). Additionally, levels of LVEDV and LVEF in group B showed no significant difference with that in group A (P<0.05). Conclusion Three-dimensional echocardiographic strain parameters could effectively evaluate left ventricular myocardial systolic dysfunction induced by early-stage liver cirrhosis.

Key words: Echocardiography, Liver cirrhosis, Left ventricular, Strain, Three dimensional