他汀类药物致肝损伤临床特点及影响因素分析

摘要/Abstract

摘要： 目的探讨他汀类药物引发肝损伤的特点。方法回顾性分析26例他汀类药物致肝损伤患者年龄、性别、肝病史、临床表现、实验室指标、服药情况及治疗等。结果 26例患者女性19例,男性7例;临床表现有纳差、乏力、尿黄等;临床分型以肝细胞损伤型为主;涉及药品5种,以辛伐他汀、阿托伐他汀、瑞舒伐他汀为主。结论他汀类药物引起肝损伤,临床表现形式多样,但转归较好。

关键词: 他汀类药物, 药物性肝损伤

Abstract: Objective To investigate the characteristics of patients with statins-induced liver injury.Methods Twenty-six patients with statins-induced liver injury were enrolled, and age, sex, liver disease history, clinical manifestations, laboratory index, drugs, treatments, etc. were retrospectively analyzed.Results Among all the patients, 19 were female and 7 were male. Clinical manifestations included poor appetite, fatigue, yellow urine and so on. Hepatocellular type was the predominant type in these cases. Five kinds of drugs were involved, mainly including simvastatin, atorvastatin, and rosuvastatin.Conclusion Patients with statins-induced liver injury had various clinical manifestations with comparatively good prognosis.

Key words: Statins, Drug-induced liver injury

陈步宽. 他汀类药物致肝损伤临床特点及影响因素分析[J]. 肝脏, 2017, 22(10): 885-887.

CHEN Bu-kuan. Clinical characteristics and associated factors in patients with statins induced liver injury[J]. Chinese Hepatolgy, 2017, 22(10): 885-887.

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