[1] Chen JL,Yuan ZH.Influence of interferon and nucleos(t)ide analogues on HBV cccDNA and functional cure of chronic hepatitis B.J Clin Hepatol,2019,35:1181-1187. [2] Lok AS, Zoulim F, Dusheiko G, et al. Hepatitis B cure: from discovery to regulatory approval. J Hepatol,2017,67:847-861. [3] Poonia B,Ayithan N,Nandi M,et al. HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T follicular helper cell axis. Sci Rep,2018,8:15296. [4] Portugal S, Obeng-Adjei N, Moir S, et al. Atypical memory B cells in human chronic infectious diseases: an interim report. Cell Immunol,2017,321:18-25. [5] Burton AR,Pallett LJ, McCoy LE,et al. Circulating and intrahepatic antiviral B cells are defective in hepatitis B. J Clin Invest,2018,128:4588-4603. [6] Salimzadeh L, Le Bert N, Dutertre C-A, et al. PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection. J Clin Invest,2018,128:4573-4587. [7] Vaeth M,Eckstein M,Shaw PJ,et al.Store-operated Ca(2+) entry in follicular T cells controls humoral immune responses and autoimmunity.Immunity,2016,44:1350-1364. [8] Wang LF,Zhang Y,Deng H.Research advances in multiple regulation of follicular helper T cells.Chin J Immunol,2016,32:1400-1404. [9] Spaan M,Kreefft K,de GRAAV GN,et al.CD4+CXCR5+ T cells in chronic HCV inflection produce less IL-21,yet are efficient at supporting B cell responses. J Hepatol,2015,62:303-310. [10] Mesquita D Jr,Cruvinel WM,Resende LS,et al.Follicular helper T cell in immunity and autoimmunity.Braz J Med Biol Res,2016,49:e5209. [11] Wang Y,Huang YY,Ma Y,et al.Expression features of follicular helper T cells in peripheral blood in patients with chronic hepatitis B.J Clin Hepatol,2018,34:58-62. [12] Li FH,Lv HM,Wang F,et al. Correlation between percentages of peripheral blood CD4+CXCR5+Tfh cells and those of FoxP3+Treg cells in patients with chronic hepatitis B virus infection. Shijie Huaren Xiaohua Zazhi,2012,20: 1100-1106. [13] Yoo JL,Braciale TJ.IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection.PLoS One ,2014,9:e105872. [14] Zhao PW,Shi X,Li C,et al.IL-33 enhances humoral immunity against chronic HBV infection through activating CD4(+) CXCR5(+) TFH cells. J Interferon Cytokine Res,2015,35:454-463. [15] Morita R, Schmitt N, Bentebibel SE, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity ,2011,34: 108-121 . [16] Wang RX, Xie RL, Song ZC. Circulating regulatory Tfh cells are enriched in patients with chronic hepatitis B infection and induce the differentiation of regulatory B cell. Experimental Cell Research,2018,365:171-176. [17] Dong QY.Dysregulated humoral immune response to hepatitis B surface antigen promotes HBV persistence. Academy of Military Sciences,2018. [18] Zoulim F. Inhibition of hepatitis B virus gene expression: a step towards functional cure. J Hepatol ,2018,68:386-388. [19] Mueller H, Wildum S,Luangsay S, et al. A novel orally available small molecule hepatitis B virus expression inhibitor. J Hepatol ,2018,68:412-420. [20] Seeger C, Mason WS. Molecular biology of hepatitis B virus infection.Virology,2015,479-480:672-686. [21] Zhou TL, Block T, Liu F, et al. HBsAg mRNA degradation induced by a dihydroquinolizinone compound depnds on the HBV posttranscriptional regulatory element. Antivir Res,2018,149:191-201. [22] Michel B,Victor P,Gheorghe P,et al. FRI-210-Establishment of high rates of functional cure of HBeAg negative chronic HBV infection with REP 2139-Mg based combination therapy: Ongoing follow-up results from the REP 401 study. J Hepatol,2019,70:e486. [23] Gane E, Verdon DJ, Brooks AE,et al. Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: a pilot study. J Hepatol,2019,71:900-907. |