关键词: 乙型肝炎肝硬化, 肝硬化性心肌病(CCM), 危险因素

Abstract: Objective To investigate the influencing factors of cirrhotic cardiomyopathy (CCM) in patients with hepatitis B-associated cirrhosis and to prevent CCM as soon as possible. Methods With strict inclusion and exclusion criteria, 45 hepatitis B-associated cirrhosis patients complicated with CCM who were hospitalized in our hospital from February 2013 to July 2015 were selected as the case group, and 100 patients without CCM in the same period were selected as the control group. A case-control study was conducted. Independent-sample t test was used to analyze the measurement data obeying normal distribution, Mann-Whitney U test was used to analyze the measurement data with non-normal distribution, χ² test was used to analyze the counting data, and multivariate logistic regression analysis was used to evaluate the effect of various factors on CCM in hepatitis B-associated cirrhosis patients. Results The Child-Pugh grade [odds ratio (OR)=3.794, 95% confidence interval (CI): 1.320~10.901], the model for end-stage liver disease (MELD) score (OR=1.218, 95% CI: 1.107~1.341), age (OR=1.079, 95% CI: 1.034~1.125) and hemoglobin (Hb) (OR=0.978, 95% CI: 0.962~0.994) were statistically significant variables affecting the development of CCM in patients with hepatitis B-associated cirrhosis. Conclusion Child-Pugh grade, MELD score, Hb and age are independent risk factors for CCM in hepatitis B-associated cirrhosis patients.

Key words: Hepatitis B-associated cirrhosis, Cirrhotic cardiomyopathy Risk factors