慢性乙型肝炎患者血清纤维蛋白原样蛋白1与HBV DNA载量的相关性分析

肝脏 ›› 2020, Vol. 25 ›› Issue (11): 1161-1164.

慢性乙型肝炎患者血清纤维蛋白原样蛋白1与HBV DNA载量的相关性分析

谢明容, 张川

625000 四川雅安市人民医院消化内科(谢明容),急诊科(张川)

收稿日期:2020-01-03 出版日期:2020-11-30 发布日期:2020-12-22
通讯作者: 谢明容,Email:xabam28@163.com
基金资助:
雅安市应用技术研究与开发资金项目(2017yyjskf09)

The analisis of the correlation between serum fibrinogen-like protein 1 and HBV DNA load in patients with chronic hepatitis B

XIE Ming-rong¹, ZHANG Chuan²

1. Department of gastroenterology,Ya'an People's Hospital,Ya'an 625000,Sichuan,China;
2. Department of Emergency treatment,Ya'an People's Hospital,Ya'an 625000,China

Received:2020-01-03 Online:2020-11-30 Published:2020-12-22
Contact: XIE Ming-rong,Email:xabam28@163.com

摘要/Abstract

摘要： 目的观察慢性乙型肝炎患者的血清纤维蛋白原样蛋白1(FLP1)与乙型肝炎病毒DNA(HBV DNA)载量表达情况,分析患者血清FLP1与HBV DNA载量的相关性。方法选取我院2017年8月至2019年10月期间就诊的204例慢性乙型肝炎患者作为研究对象,根据肝纤维化的严重程度对患者进行分组,分别为S0组(42例)、S1组(39例)、S2组(46例)、S3组(38例)、S4组(39例)。比较5组患者的血清FLP1水平、HBV DNA载量拷贝数的对数值及HBV DNA阳性率,根据HBV DNA载量的拷贝数对数值将患者整体分为＜3、3~4、5~6、＞6等4组,比较4组的血清FLP1水平;经双变量直线相关检验,分析慢性乙型肝炎患者血清FLP1水平与HBV DNA载量的相关性。结果随着慢性乙型肝炎患者的肝纤维化分级加重,患者的血清FLP1水平降低、HBV DNA载量拷贝数的对数值升高,HBV DNA阳性检出率升高,组间比较差异有统计学意义(P<0.05);随着HPV-DNA载量对数值的升高,患者血清FLP1水平呈下降趋势,各组间比较差异有统计学意义(P<0.05);经双变量Pearson直线相关检验结果显示,慢性乙型肝炎患者的血清FLP1水平与HBV DNA载量拷贝数的对数值呈负相关(r=-0.584,P<0.001)。结论随着慢性乙型肝炎患者FLP1水平降低,患者HBV DNA载量的对数值增加,阳性检出率升高,患者血清FLP1水平与HBV DNA载量间呈负相关,临床工作中可考虑通过检测血清FLP1水平,来监测慢性乙型肝炎患者体内病毒复制情况。

关键词: 慢性乙型肝炎, HBV DNA载量, 血清纤维蛋白原样蛋白1, 相关性

Abstract: Objective To observe the serum level of fibrinogen-like protein 1 (FLP1) and hepatitis B virus-deoxyribonucleic acid (HBV DNA) load in patients with chronic hepatitis B (CHB),and analyze the correlation between them.Methods 204 patients with chronic hepatitis B were divided into S0 group (N=42 cases),S1 group (N=39 cases),S2 group (N=46 cases),S3 group (N=38 cases) and S4 group (N=39 cases) according to their gradings of liver fibrosis stages by liver biopsies.The serum FLP1 level,the logarithmic value of the copy numbers of HBV DNA load,and the positive rate of HBV DNA were compared among the five groups.According to the logarithmic value of HBV DNA copy numbers,the patients were divided into <3 group,3~4 group,5~6 group,>6 group.The serum FLP1 levels in these four groups were compared.Moreover,the correlation between serum FLP1 level and HBV DNA load in patients with chronic hepatitis B was analyzed by bivariate linear correlation test.Results With the progression of liver fibrosis in patients with chronic hepatitis B,the serum FLP1 level decreased,whereas the logarithmic value of HBV DNA copy numbers increased,accompanied by an increased positive detection rate of HBV-DNA (P<0.05);With the increase of the logarithmic value of HPV DNA load,the serum FLP1 level showed a downward trend with statistically significant differences (P<0.05);By bivariate pearson linear correlation test it was showed that serum FLP1 levels of patients with chronic hepatitis B were negatively correlated with the logarithmic value of HBV DNA copy numbers (r=-0.584,P<0.001).Conclusion The serum level of FLP1 in chronic hepatitis B patients decrease with the increment of logarithmic value of HBV DNA load and the positive detection rate.There is a negative correlation between serum FLP1 level and HBV DNA load in CHB patients.Serum FLP1 level may therefore be considered as a clinical parameter to monitor the viral replication.

Key words: Chronic hepatitis B, HBV DNA load, Serum fibrinogen-like protein 1

谢明容, 张川. 慢性乙型肝炎患者血清纤维蛋白原样蛋白1与HBV DNA载量的相关性分析[J]. 肝脏, 2020, 25(11): 1161-1164.

XIE Ming-rong, ZHANG Chuan. The analisis of the correlation between serum fibrinogen-like protein 1 and HBV DNA load in patients with chronic hepatitis B[J]. Chinese Hepatolgy, 2020, 25(11): 1161-1164.

参考文献

[1] Lsy T,Covert E,Wilson E,et al.Chronic Hepatitis B Infection:A Review.Jama,2018,319:1802-1813.
[2] 武永萍,魏占芳,石栓柱,等.瞬时弹性超声成像在评价乙型肝炎肝纤维化严重程度中的价值.肝脏,2019,24:905-907.
[3] Cao J,Chi H,Yu T,et al.Off-Treatment Hepatitis B Virus (HBV) DNA Levels and the Prediction of Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy in Patients With Chronic Hepatitis B:A Prospective Stop Study.J Infect Dis,2017,215:581-589.
[4] 李媛媛.慢性乙型肝炎患者血清HBeAg阳性或阴性与HBV DNA水平的关系.贵州医药,2009,33:436-438.
[5] Zou Z,Cai Y,Chen Y,et al.Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3.Mol Med Rep,2015,12:2089-2097.
[6] 陈美娟,黄海军,戴伊宁,等.血清纤维蛋白原样蛋白1与慢性乙型肝炎肝纤维化程度的相关性.国际流行病学传染病学杂志,2019,46:47-50.
[7] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015更新版).中华肝脏病杂志,2015,33:321-340.
[8] Feng J,Huang J,Li Z.Kushenin combined with adefovir dipivoxil affects the HBV-DNA load in serum,immune functions and liver functions of patients with chronic hepatitis B.Exp Therap Med,2017,14:5837-5842.
[9] 蔡兴龙.乙肝患者血清HBeAg与HBV-DNA定量的相关性分析.河北医学,2019,25:820-823.
[10] 程振波,谭黎明,李建英,等.乙型肝炎病毒感染者血清HBV—LP检测意义及其与PreS1抗原、HBVDNA之间关系的研究.实用预防医学,2016,23:487-489.
[11] 董博,胡海石,王德景,等.慢性乙型肝炎病毒感染患者血清HBV-LP水平与HBV-DNA及HBeAg的关系及临床意义.实用预防医学,2019,26:490-492.
[12] Demchev V,Malana G,Vangala D,et al.Targeted Deletion of Fibrinogen Like Protein 1 Reveals a Novel Role in Energy Substrate Utilization.PLoS One,2013,8:e58084.
[13] Liu Z,Ukomadu C.Fibrinogen-like protein 1,a hepatocyte derived protein is an acute phase reactant.Biochem Biophys Res Commun,2008,365:729-734.
[14] 李娜,李宏斌,朱蕾,等.纤维蛋白原和血常规检测对乙型肝炎的诊断价值.国际病毒学杂志,2016,23:38-40.
[15] 董晓玉.联合检测凝血四项、D二聚体、纤维蛋白/纤维蛋白原降解产物对肝病患者的临床价值.血栓与止血学,2016,22:283-285.
[16] Milani S,Aliakbarian M,Amouian S.Afibrinogenemia Acquired by Liver Transplant.Exp Clin Transplant,2019,17:692-694.
[17] 李娴.生理体液法分析肝病患者的氨基酸研究.天津医科大学,2010.
[18] 钟政荣,徐云侠.乙型肝炎患者血清乙型肝炎病毒-DNA与常用血清标志物的相关性分析.蚌埠医学院学报,2015,40:1387-1389.