基于核磁共振波谱与影像技术分析肝脏的糖脂代谢能力

摘要/Abstract

摘要： 随着科技不断发展,核磁共振技术(NMR)愈发成熟。越来越多研究证实了NMR技术在肝脏疾病成像、诊断方面具有不可忽视的地位,通过NMR波谱(MRS)和NMR影像(MRI)数据分析,有望实现无创诊断临床肝病组织学表现。确定分析肝脏组织糖脂代谢的NMR方法,并逐渐提高其检测精确度,会对慢性肝病(尤其是代谢性肝病)的诊断具有重要意义。在现有理论成果基础上,利用基于稳定同位素的杂核MRS 和MRI,或者新型的化学交换饱和转移MRI,可以进一步研究肝组织的糖代谢过程。对于脂代谢的分析,主要应用方法有超极化13C磁共振、基于MRI的质子密度脂肪含量测定、同位素标记代谢通量分析等方法。本文将介绍各种MRS和MRI技术分析肝脏糖脂代谢能力的方法及其优缺点,希望能为相关研究提供技术思路。

关键词: 核磁共振波谱, 核磁共振成像, 肝脏, 糖代谢, 脂代谢

李纪伟, 黎韵诗, 刘亚婷, 曹誉, 赖厚桦, 易佩伟, 汪艳. 基于核磁共振波谱与影像技术分析肝脏的糖脂代谢能力[J]. 肝脏, 2021, 26(6): 700-703.

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