HBsAg定量在HBeAg阴性慢性HBV感染患者中的临床应用及价值

肝脏 ›› 2021, Vol. 26 ›› Issue (7): 713-716.

HBsAg定量在HBeAg阴性慢性HBV感染患者中的临床应用及价值

王捷骁, 干沁怡, 谢青

200025 上海交通大学医学院附属瑞金医院感染科

收稿日期:2021-02-25 出版日期:2021-07-31 发布日期:2021-09-02
通讯作者: 干沁怡,Email:nhlinda@sjtu.edu.cn
基金资助:
上海市临床重点专科(感染病学)( shslczdzk01103)、国家自然科学基金(81770587,82070604,82000588)、十三五“科技部重大专项”(2017ZX10203201-008, 2018ZX09201016-003-001, 2017ZX10202202-005-004)

Received:2021-02-25 Online:2021-07-31 Published:2021-09-02

摘要/Abstract

摘要： HBV感染在世界范围内分布广泛,如何更好地进行CHB管理仍是全球面临的挑战和难题。近年来抗HBV治疗有很多进展,但仍然缺少能使CHB患者达到HBsAg清除这一最终治疗目标的有效手段。研究表明,乙型肝炎表面抗原定量(qHBsAg)可以预测非活动性HBV感染的存在,而血清中HBsAg水平的变化可以预测1~3年内的HBsAg清除。监测qHBsAg在肝炎发作和抗病毒治疗应答评估中十分重要,尤其是对停药节点的判断和对复发的预测。这些发现如果加以合理应用,则可优化HBeAg阴性的慢性乙型肝炎患者的治疗方案,从而向精准治疗更进一步。

关键词: 乙型肝炎表面抗原定量, 乙型肝炎病毒, 乙型肝炎e抗原, 慢性乙型肝炎

王捷骁, 干沁怡, 谢青. HBsAg定量在HBeAg阴性慢性HBV感染患者中的临床应用及价值[J]. 肝脏, 2021, 26(7): 713-716.

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