关键词: 巨大肝血管瘤, 病理特征, 栓塞材料, 临床疗效

Abstract: Objective To study the clinical characteristics of patients with giant hepatic hemangioma and observation of the application value of different interventional embolization materials. Methods The clinical data of 84 patients with giant hepatic hemangioma from March 2017 to March 2020 were collected, all patients received color Doppler Flow Imaging (CDFI) examination and interventional embolization, the CDFI hemodynamic characteristics were recorded.84 patients were divided into observation group (n=48) and control group (n=36) according to the different embolization materials. The observation group was treated with pingyangmycin iodized oil embolization, and the control group was treated with bleomycin iodized oil embolization. The treatment effects of the two groups were compared, and the clinical effects of patients with different hemodynamic characteristics were recorded. Results The results of CDFI examination showed that there were 23 cases of high blood supply in the 84 patients, which accounting for 27.38%, the 47 cases of low blood supply type, which accounting for 55.95%, 14 cases of poor blood supply, which accounting for 16.67%. The tumor diameter in the observation group at 3 months after treatment was significantly lower than that in the control group, the difference was statistically significant (P<0.05). There was no statistically significant difference in hospitalization time, hospitalization expenses and incidence of adverse reactions between the two groups (P>0.05). The overall curative effect of patients in the high blood supply group was significantly better than that of the low blood supply group and the poor blood supply group, the difference was statistically significant (P<0.05). The results of receiver operator characteristic (ROC) analysis showed that the AUC of diameter of hepatic hemangioma for judging the effect of pingyangmycin iodized oil embolization was 0.743 (95% CI=0.559～0.657, SE=0.079, P=0.028), the sensitivity was 0.833, the specificity was 0.583, and the cutoff value was 13.21 cm. Conclusion The patients with giant hepatic hemangioma are mainly of high blood supply and low blood supply. The pingyangmycin iodized oil embolization material is better than bleomycin in the treatment of giant hepatic hemangioma, especially for the high blood supply and the tumor diameter less than 13.21 cm, and the effect was significant.

Key words: Giant hepatic hemangioma, Pathological features, Embolic material, Clinical efficacy