ATLI患者遗传易感性及新型生物标志物的研究进展

摘要/Abstract

摘要： 抗结核药物性肝损伤(anti—tuberculosis drug—induced liver injury,ATLI )是结核防治工作中较为严重的并发症,有一定的致死率。其被诸多研究证实与年龄、性别、基础疾病等均有关系,当然遗传易感性在ATLI的发生中也起到了不可或缺的作用。抗结核药物性肝损伤的诊断主要依靠RUCAM量表,该诊断方法是一种排除性诊断,有一定的局限性。本文就ATLI患者的遗传易感性及RUCAM评分量表外的诊断方法作一综述,为结核病防治工作提供一定的参考价值,为临床中ATLI的诊治提供一定的思路。

关键词: 抗结核药物性肝损伤, 遗传易感性, RUCAM评分量表, 诊断

聂伟杰, 刘家旗, 张锦, 孟存英. ATLI患者遗传易感性及新型生物标志物的研究进展[J]. 肝脏, 2021, 26(7): 807-810.

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