丁型肝炎动物模型的研究进展

摘要/Abstract

摘要： 丁型肝炎大多为乙型肝炎患者重叠感染丁型肝炎病毒(Hepatitis delta virus,HDV),可呈现急性或慢性病程,容易发展为肝硬化,增加患原发性肝癌的风险,被认为是最严重的肝炎类型。目前仍缺少有效治疗丁型肝炎的药物,常见的实验动物并非HDV的天然宿主而未能完全反映HDV感染生活周期,因此迫切需要寻找理想的动物模型来深入研究HDV感染过程及其与宿主的相互作用机制,为探索新的治疗方法提供研究平台。

关键词: HDV, 丁型肝炎, 动物模型, HBV

姚婷, 臧国庆, 陈小华. 丁型肝炎动物模型的研究进展[J]. 肝脏, 2021, 26(7): 814-817.

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