15例急性药物性肝损伤伴急性肾损伤患者的临床特征分析

肝脏 ›› 2021, Vol. 26 ›› Issue (8): 895-898.

15例急性药物性肝损伤伴急性肾损伤患者的临床特征分析

付双楠, 何婷婷, 张宁, 周超, 张晶晶, 王宣, 李昕, 孙志华, 刘鹏程, 宫嫚

100039 北京解放军总医院第五医学中心中医肝病科

收稿日期:2021-02-24 出版日期:2021-08-31 发布日期:2021-09-29
通讯作者: 宫嫚,Email:gongman302@ 163.com
基金资助:
国家“十三五”科技重大专项课题( 2018ZX10725506-002);国家“十三五”科技重大专项课题( 2018ZX10303502-002-019)

Clinical characteristics of 15 patients with drug-induced liver and kidney injuries

FU Shuang-nan, HE Ting-ting, ZHANG Ning, ZHOU Chao, ZHANG Jing-jing, WANG Xuan, LI Xin, SUN Zhi-hua, LIU Peng-cheng, GONG Man

Department of TCM Hepatology,The Fifth Medical Center of PLA General Hospital, Beijing 100039, China

Received:2021-02-24 Online:2021-08-31 Published:2021-09-29
Contact: GONG Man, Email: gongman302@ 163.com

摘要/Abstract

摘要： 目的分析急性药物性肝损伤伴急性肾损伤的临床表现、实验室检查等临床特征。方法回顾性分析2011年1月1日至2019年12月31日解放军总医院第五医学中心收治的急性DILI伴AKI患者的临床资料,探讨临床特征。结果 15例患者中女9例,8例年龄≥60岁,年龄为(64.9±10.3)岁。临床表现以纳差最常见为10例,其次为乏力9例、尿黄8例。临床分型以肝细胞型为主,有7例。肝损伤程度均为3级及以上,肾损伤以1期为主,有9例。并发症以腹水多见。结论急性DILI伴AKI主要见于老年人,临床分型以肝细胞型为主,肝损伤程度较重,并发症影响预后。

关键词: 药物, 肝损伤, 肾损伤, 疾病特征

Abstract: Objective To analyze the clinical manifestations, laboratory tests and other clinical features of acute drug-induced liver and kidney injuries.Methods The clinical data of patients with acute DILI and AKI admitted to the Fifth Medical Center of PLA General Hospital from January 1, 2011 to December 31, 2019 were retrospectively analyzed, and the clinical characteristics were discussed.Results Among the 15 patients, 9 were female, 8 were ≥60 years old, with an average age of 64.88±10.30 years old. The most common clinical manifestations were anorexia (10 cases), followed by fatigue (9 cases) and yellow urine (8 cases). The main clinical classification is hepatocyte type (46.67%). The degree of liver damage was all grade 3 and above, and the main type of kidney damage was stage 1 (60%). Ascites was the most common complication.Conclusion Acute DILI with AKI is mainly seen in the elderly. The clinical classification of acute DILI with AKI is mainly hepatocyte type,and the degree of liver damage is severe. The appearance of complications affects the patients’ prognosis.

Key words: Drug induced liver and kidney Injuries, Disease attributes

付双楠, 何婷婷, 张宁, 周超, 张晶晶, 王宣, 李昕, 孙志华, 刘鹏程, 宫嫚. 15例急性药物性肝损伤伴急性肾损伤患者的临床特征分析[J]. 肝脏, 2021, 26(8): 895-898.

FU Shuang-nan, HE Ting-ting, ZHANG Ning, ZHOU Chao, ZHANG Jing-jing, WANG Xuan, LI Xin, SUN Zhi-hua, LIU Peng-cheng, GONG Man. Clinical characteristics of 15 patients with drug-induced liver and kidney injuries[J]. Chinese Hepatolgy, 2021, 26(8): 895-898.

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