不同胎龄早产儿和不同出生体质量新生儿的肝生化变化及临床意义

肝脏 ›› 2021, Vol. 26 ›› Issue (9): 1036-1040.

不同胎龄早产儿和不同出生体质量新生儿的肝生化变化及临床意义

朱理佳, 马晓丹, 段江, 李檬, 黄永坤

650031 云南昆明医科大学第一附属医院儿科(朱理佳,段江,李檬,黄永坤);昆明医科大学第六附属医院/玉溪市人民医院儿科(朱理佳,马晓丹)

收稿日期:2020-10-25 出版日期:2021-09-30 发布日期:2021-10-22
通讯作者: 黄永坤,Email:hykkmyncnwd@163.com
基金资助:
昆明医科大学第一附属医院博士基金项目(2019BS016)

Changes and clinical significance of liver function in premature infants with different gestational ages and newborns with different birth weights

ZHU Li-Jia^1,2, MA Xiao-dan², DUAN Jiang¹, LI Meng¹, HUANG Yong-kun¹

1. Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Yunnan 650031, China;
2. The Sixth Affiliated Hospital of Kunming Medical University/Department of Hematology, Yuxi People's Hospital, Yunnan 653100, China

Received:2020-10-25 Online:2021-09-30 Published:2021-10-22
Contact: HUANG Yong-kun,Email:hykkmyncnwd@163.com

摘要/Abstract

摘要： 目的探讨丙氨酸氨基转移酶(alanine amino transferase,ALT)、前白蛋白(preAlbumin,PAB)、白蛋白(Albumin,Alb)碱性磷酸酶(alkaline phosphatase,ALP)、γ-谷氨酰转肽酶(gamma-glutamyl transferase,γ-GT)及总胆汁酸(total bile acid, TBA)在不同胎龄早产儿、不同出生体质量儿治疗中的临床价值。方法回顾性分析204例不同胎龄早产儿、206例不同出生体质量新生儿治疗前后ALT、PAB、Alb、ALP、GGT、TBA指标的变化。比较分析各生化指标在不同胎龄早产儿、不同出生体质量新生儿各组中和组间的差异。结果晚期早产儿组、中期早产儿组、极早产儿组及正常出生体重儿组、低出生体质量儿组、极低出生体重儿组治疗后Alb、PA均高于治疗前,其变化最为显著,均具有统计学意义(P<0.05)。治疗后随肝功能恢复、完善,ALT、γ-GT、TBA降低。不同胎龄早产儿组中晚期早产儿组、中期早产儿组、极早产儿组间及不同出生体质量组中正常出生体质量儿组、低出生体质量儿组、极低出生体质量儿组间,胎龄越小、体质量越小,肝脏合成Alb、PA、ALT、ALP、γ-GT、TBA的能力和排泄能力亦有所差异。结论在不同胎龄、不同出生体质量儿治疗后Alb、PA明显增多,ALT、γ-GT明显减低,以Alb、PA变化最显著,可作为监测肝功能的重要指标。随胎龄越小、体质量越小,肝脏功能易受影响,其合成能力、储备和排泄能力越差。

关键词: 新生儿, 胎龄, 体质量, 肝功能, 变化, 临床意义

Abstract: Objective To explore clinical value of alanine amino transferase (ALT), preAlbumin (PAB), Albumin (Alb), alkaline phosphatase (ALP), g-glutamyl transferase (gamma-glutamyl transferase, GGT) and total bile acid (TBA) in the treatment of premature infants with different gestational ages and newborns with different birth weights. Methods The changes of ALT, PAB, Alb, ALP, GGT, TBA in 204 premature infants of different gestational ages and 206 newborns of different birth weights before and after treatment were retrospectively analyzed. We compared and analyzed the differences of various biochemical indicators in different gestational age preterm infants and different birth weight newborns. Results 1. Alb and PAB in late, middle, very preterm infants groups, and normal, low, very low birth weight newborns groups were higher than those before treatment, and the changes were the most statistically significant (P<0.05). With the recovery and improvement of liver function after treatment, ALT, GGT and TBA reduced. 2. Inter group differences: The younger the gestational age and the lighter the birth weight, the ability of liver to synthesize Alb, PAB, ALT, ALP, GGT and TBA were also different between groups of premature infants with different gestational ages and newborns with different birth weights respectively. Conclusion 1. In different gestational ages premature infants and different birth weight newborns after treatment, Alb and PAB increased significantly, and ALT and GGT decreased significantly. Alb and PAB have the most significant changes. Alb and PAB can be used as important indicators for monitoring liver function. 2. With the younger the gestational age and the lighter the weight, the liver function is easily affected, and its synthesis capacity, reserve and excretion capacity are worse.

Key words: New borns, Gestational age, Weight, Liver function, Changes, Clinical significance

朱理佳, 马晓丹, 段江, 李檬, 黄永坤. 不同胎龄早产儿和不同出生体质量新生儿的肝生化变化及临床意义[J]. 肝脏, 2021, 26(9): 1036-1040.

ZHU Li-Jia, MA Xiao-dan, DUAN Jiang, LI Meng, HUANG Yong-kun. Changes and clinical significance of liver function in premature infants with different gestational ages and newborns with different birth weights[J]. Chinese Hepatolgy, 2021, 26(9): 1036-1040.

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