非酒精性脂肪性肝炎肝脏巨噬细胞极化的影响因素

摘要/Abstract

摘要： 目前,非酒精性脂肪性肝病(NAFLD) 是世界范围内最常见的慢性肝病病因,可进一步发展为肝纤维化、肝硬化和肝癌。然而,NAFLD发病机制尚未完全明确。近年来,巨噬细胞作为调节肝脏稳态的重要角色一直备受关注。肝脏巨噬细胞极化参与了非酒精性脂肪性肝炎(NASH)的发病和进展,“促炎”的M1型巨噬细胞和“抗炎”的M2型巨噬细胞分别与NASH的发生和改善相关。M1型和M2型巨噬细胞之间的比例存在动态平衡,M1/M2比例失衡可能是NAFLD发病机制的关键。本文针对影响NASH肝脏巨噬细胞极化的因素进行阐述,旨在更深入地了解巨噬细胞极化在NASH发病机制中的作用,为NAFLD的治疗提供参考。

刘百怡, 饶慧瑛. 非酒精性脂肪性肝炎肝脏巨噬细胞极化的影响因素[J]. 肝脏, 2021, 26(10): 1079-1081.

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