细胞焦亡参与非酒精性脂肪性肝病的相关研究进展

摘要/Abstract

摘要： 非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是最为常见的慢性肝病,导致了十分严重的卫生经济负担。细胞焦亡是依赖于半胱氨酸天冬氨酸蛋白酶(caspase)-1/4/5/11的新型程序性细胞死亡,大量的研究显示其在NAFLD的致病中发挥了重要的调控作用。非酒精脂肪性肝炎(non-alcoholic steatohepatitis,NASH)是NAFLD的严重类型,研究证据显示,细胞焦亡在NAFLD进展为NASH的过程中也起着重要的调节作用,且细胞焦亡相关生物学标志物如IL-1β、caspase-1等可用于NASH的诊断及评估。目前临床上并无针对NAFLD的有效治疗药物,基于细胞焦亡机制在NAFLD/NASH致病及进展中的重要调控作用,大量的研究也尝试开发基于干预细胞焦亡通路的治疗药物,虽然距离临床实际应用仍有一定差距,但也为探寻NAFLD的有效治疗方法提供了重要参考。基于此,本文对上述方面的研究进展进行了综述。

关键词: 细胞焦亡, 炎症小体, 非酒精性脂肪性肝病, 非酒精性脂肪性肝炎, 半胱氨酸天冬氨酸蛋白酶

朱鹏, 彭旸, 吴莉莉, 覃刚. 细胞焦亡参与非酒精性脂肪性肝病的相关研究进展[J]. 肝脏, 2021, 26(11): 1290-1293.

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