关键词: 中性粒细胞CD64, 降钙素原, 慢加急性肝衰竭, 抗感染, 相关性

Abstract: Objective To explore the correlation between neutrophil CD64 (nCD64) in combined with procalcitonin (PCT) and anti-infection ability of patients with acute-on-chronic liver failure (ACLF). Methods Eighty patients with ACLF admitted to Zhuhai People's Hospital from 2019 to 2020 were randomly divided into infection group and non-infection group, with 40 cases in each group. According to the treatment effect, the infection group was divided into three subgroups: high risk group, medium risk group and low risk group. The venous blood of patients was collected, and the levels of nCD64 and PCT in serum were detected. The receiver operating characteristic curve (ROC) was drawn and the area under the curve (AUC) was calculated. Results There was no significant difference in general data such as gender and age between the two groups (P>0.05). The levels of nCD64 and PCT in infected group were higher than those in non-infected group (P<0.01). The levels of nCD64 and PCT in high-risk group were (83.56±16.48)% and (3.65±2.43)ng/mL, which were significantly higher than those in middle-risk group [(75.63±17.54)%, (2.28±2.03) ng/mL] and low-risk group [(70.44±14.29)%, (0.82±0.02)ng/mL]; the AUC of nCD64, PCT and nCD64 combined PCT were 0.9212 (95% CI 0.861-0.982), 0.9125 (95% CI 0.835-0.990) and 0.9731 (95% CI 0.876-0.994), respectively, all of which were greater than 0.9. The AUC of nCD64 combined with PCT was higher than that of nCD64 and PCT alone. Conclusion The levels of nCD64 and PCT are closely related to the anti-infection ability of ACLF patients, and the diagnostic efficiency of nCD64 combined with PCT is higher than that of nCD64 and PCT alone, which can be used to evaluate the severity of infection diseases in ACLF patients.

Key words: Neutrophil CD64, Procalcitonin, Acute-on-chronic liver failure, Anti-infection, Correlation