微小RNA参与调控肝细胞癌耐药的相关研究进展

摘要/Abstract

摘要： 肝细胞癌(hepatocellular carcinoma,HCC)是临床上十分常见的恶性肿瘤,随着全身化疗药物的广泛应用,HCC对药物的耐药问题也日渐凸显,对患者的总体预后造成了不良的影响。微小RNA(micro-RNA,miRNA)属于非编码RNA,其在HCC的致病及进展中发挥着重要的调控作用。随着对miRNA功能的深入研究了解,其在HCC耐药中的作用也逐渐得到临床的重视。靶向调控miRNA来改善HCC耐药也逐渐成为研究的热点,也显示出积极正面的结果,但目前的研究结果仍主要停留在细胞及动物模型层面,距离临床实际应用仍有较大的差距,下步还需要更深入的研究探索。

关键词: 肝细胞癌, 微小RNA, 索拉非尼, 顺铂, 阿霉素, 耐药

罗舒, 陈非, 秦蓉声, 陈英, 朱鹏. 微小RNA参与调控肝细胞癌耐药的相关研究进展[J]. 肝脏, 2022, 27(1): 116-119.

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