妊娠期肝内胆汁淤积症的致病因素和药物治疗进展

摘要/Abstract

摘要： 妊娠期肝内胆汁淤积症(ICP)是妊娠期最常见的肝脏疾病,主要表现为皮肤瘙痒、黄疸、血清胆汁酸和肝酶水平异常升高,与遗传、环境、女性性激素水平和免疫功能失调等相关。ICP对母儿的危害较大,易发生早产、胎儿宫内窘迫、死胎、产后出血和远期肝胆疾病,早期诊断和有效干预很重要。在产科干预的基础上给予药物治疗,多能缓解临床症状,降低产科风险,改善妊娠结局。本文综述了ICP的致病因素和药物治疗的现状。

关键词: 妊娠期肝内胆汁淤积症, 致病因素, 药物治疗, 进展

龚燕, 龚杰. 妊娠期肝内胆汁淤积症的致病因素和药物治疗进展[J]. 肝脏, 2022, 27(2): 247-249.

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