[1] Lin DC, Mayakonda A, Dinh HQ, et al. Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. Cancer Res,2017,77(9):2255-2265.
[2] 陈怡, 邵荣光. 肝癌干细胞的分子标记与靶向治疗. 中国医药生物技术,2011,6(01):40-43.
[3] McGranahan N, Swanton C. Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future. Cell,2017,168(4):613-628.
[4] Dagogo-Jack I, Shaw AT. Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol,2018,15(2):81-94.
[5] Beck B, Blanpain C. Unravelling cancer stem cell potential. Nature Reviews Cancer,2013,13(10):727-738.
[6] 成怡斐, 高强. 肝癌微环境时空异质性与个体化免疫治疗. 中国细胞生物学学报,2022,44(04):559-571.
[7] 李瀚旻, 高翔. 肝癌肝再生微环境影响肝干细胞恶性转化肝癌及其异质性的机制. 中西医结合肝病杂志. 2021;31(08):673-678.
[8] Li S, Garrett-Bakelman FE, Chung SS, et al. Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia. Nat Med,2016,22(7):792-799.
[9] 徐伟, 李高峰, 李权, 等. 肝癌肿瘤异质性的临床新进展. 肝胆胰外科杂志,2016,28(01):84-86.
[10] Sormendi S, Wielockx B. Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment. Front Immunol,2018,9:40.
[11] Bedard PL, Hansen AR, Ratain MJ, et al. Tumour heterogeneity in the clinic. Nature,2013,501(7467):355-364.
[12] 楼煜. 基于多组学数据的肝癌瘤内异质性与肿瘤免疫微环境研究 [博士]: 浙江大学,2021.
[13] 伍睿. 基于空间转录组学技术对原发性肝癌空间异质性的研究 [博士]: 中国人民解放军海军军医大学,2021.
[14] Clevers H. The cancer stem cell: premises, promises and challenges. Nat, Med,2011,17(3):313-319.
[15] Klein CA. Selection and adaptation during metastatic cancer progression. Nature, 2013, 501(7467):365-372.
[16] 王娜, 赵利楠, 韩泽广. 单细胞测序技术在肝癌研究中的应用. 中国生物化学与分子生物学报,2020,36(05):488-493.
[17] Sell S, Dunsford HA. Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am J Pathol,1989,134(6):1347-1363.
[18] Aizarani N, Saviano A, Sagar, et al. A human liver cell atlas reveals heterogeneity and epithelial progenitors. Nature,2019,572(7768):199-204.
[19] Jamal-Hanjani M, Wilson GA, McGranahan N, et al. Tracking the Evolution of Non-Small-Cell Lung Cancer. New Engl J Med,2017,376(22):2109-2121.
[20] 张文锋, 冯凯. 肿瘤异质性:肝癌干细胞有序的分化潜能. 检验医学与临床,2014,11(21):3067-3069. |
