孟德尔随机化分析在非酒精性脂肪性肝病危险因素研究中的应用

摘要/Abstract

摘要： 非酒精性脂肪性肝病(NAFLD)已经成为世界上最流行的慢性肝病,与不良的生活方式、肥胖、糖尿病及血脂异常等代谢疾病密切相关,目前尚无被批准的药物。对NAFLD患者危险因素的早期识别和针对性治疗有助于减轻医疗经济负担。孟德尔随机化(MR)是一种以遗传变异为工具变量的因果推断法,能够有效克服传统观察性研究中的混杂偏倚和反向因果,近来受到广泛的应用。本文围绕MR研究在NAFLD危险因素中的应用进行综述,旨在为NAFLD的防治提供依据。

关键词: 非酒精性脂肪性肝病, 孟德尔随机化, 危险因素, 代谢综合征

邓朝华, 施军平. 孟德尔随机化分析在非酒精性脂肪性肝病危险因素研究中的应用[J]. 肝脏, 2023, 28(7): 749-750.

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