靶向cccDNA以实现慢性乙型肝炎治愈

摘要/Abstract

摘要： 慢性乙型肝炎病毒(HBV)感染是全球性的重要公共问题,约有2.96亿慢性感染者。HBV共价闭合环状DNA (cccDNA)以微染色体的形式稳定存在于被感染的肝细胞核内,难以被现有的抗病毒药物靶向清除,因此被认为是HBV感染慢性化的关键因素。为实现慢性乙型肝炎(CHB)的临床治愈甚至完全治愈,我们迫切需要针对cccDNA的治疗策略。我们总结了目前cccDNA形成和调控的相关机制,并讨论通过靶向cccDNA以实现乙型肝炎治愈的可能策略。

梁红妍, 申笙, 孙剑. 靶向cccDNA以实现慢性乙型肝炎治愈[J]. 肝脏, 2023, 28(8): 887-888.

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