丙型肝炎病毒感染合并2型糖尿病的相关研究进展

摘要/Abstract

摘要： 丙型肝炎病毒(hepatitis C virus, HCV)感染和2型糖尿病(type 2 diabetes mellitus, T2DM)是两种慢性疾病,在全球范围内造成严重的健康和经济负担,两者之间的关系复杂双向。一方面,HCV感染通过诱导胰岛素抵抗、触发炎症反应、使肝脏脂肪变性等多种机制增加T2DM患病率,以及发生相关并发症的风险;另一方面,作为丙型病毒性肝炎最常见的肝外表现之一,T2DM的发生加剧了一系列肝脏不良结局。目前,随着直接抗病毒药物(direct-acting antiviral agents, DAA)的引入,不仅可以降低肝脏相关结局的发生风险,而且可以改善T2DM患者的血糖控制及降低并发症的发生风险。本文就HCV感染合并T2DM的相关病理生理机制、相互作用及目前治疗进行综述。

关键词: 丙型肝炎病毒, 2型糖尿病, 胰岛素抵抗, 直接抗病毒药物

张心怡, 贺娜, 张粉娜, 孙荣荣, 王梓依, 郝帅, 王辉, 边娜娜, 闫红林. 丙型肝炎病毒感染合并2型糖尿病的相关研究进展[J]. 肝脏, 2024, 29(3): 355-357.

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