非病毒相关肝细胞癌的防治进展

摘要/Abstract

摘要： 肝细胞癌(HCC)是癌症相关死亡的主要原因。近年来,随着乙型肝炎抗病毒药物的推广、乙型肝炎疫苗接种的普及及直接抗丙型肝炎病毒药物的诞生,目前HCC的病因构成比已逐渐由嗜肝病毒转向非病毒性因素。其中肥胖与2型糖尿病的普遍流行使得非病毒相关HCC发病率迅速增加。有研究显示,非酒精性脂肪性肝炎(NASH)、酒精性肝硬化、自身免疫性肝病(AILD)及一些药物毒素是HCC发展的独立危险因素。相较于病毒性肝细胞癌,非病毒性HCC发病机制复杂且部分对免疫治疗不敏感,因此加强对HCC高风险人群的筛查和监测,对预防非病毒相关HCC的发展与预后具有重要意义。本综述旨在总结目前非病毒相关HCC的筛查监测方案及近期免疫治疗药物的进展,并给出相应的预防策略,以供临床借鉴和参考。

关键词: 非病毒相关肝细胞癌, 危险因素, 监测, 防治

王梓依, 贺娜, 张粉娜, 张心怡, 郝帅, 孙荣荣, 王辉, 边娜娜, 闫红林. 非病毒相关肝细胞癌的防治进展[J]. 肝脏, 2024, 29(4): 478-482.

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