调控HNF4α诱导肝细胞癌分化的机制进展

摘要/Abstract

摘要： 肝细胞核因子4α(HNF4α)是诱导肝细胞癌(HCC)分化中重要的开关因子,HNF4α甚至可重编程肝癌细胞为肝样细胞。在此过程中,调控HNF4α的上游因子有肝细胞核因子6等转录因子。另外,非编码RNA对HNF4α的调控也很重要。此外,去甲基化酶1011易位甲基胞嘧啶双加氧酶-1会诱导HNF4α启动子的去甲基化,启动HCC分化,抑制精氨酸甲基转移酶5也有类似的效果。本文将近年来在诱导肝细胞癌分化过程中激活HNF4α基因、非编码RNA及去甲基化修饰及相关通路等研究加以综述。

关键词: 肝细胞癌, 分化, HNF4α, 非编码RNA, 去甲基化

丁一桁, 贾婧轩, 齐锦生, 栗彦宁, 郑丽. 调控HNF4α诱导肝细胞癌分化的机制进展[J]. 肝脏, 2024, 29(7): 874-877.

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