超声引导下聚桂醇硬化治疗对肝囊肿患者肝生化指标及Cor、AD、NE水平的影响

肝脏 ›› 2024, Vol. 29 ›› Issue (6): 714-718.

超声引导下聚桂醇硬化治疗对肝囊肿患者肝生化指标及Cor、AD、NE水平的影响

郝栋, 王晨曦, 张坤杰

473400 河南唐河县中医院外二科(郝栋);473000 河南南阳医学高等专科学校第一附属医院普外四科(王晨曦);450000 河南河南中医药大学第一附属医院普外一区(张坤杰)

收稿日期:2024-02-01 出版日期:2024-06-30 发布日期:2024-08-28
基金资助:
河南省医学科技攻关计划项目(LHGJ20200905)

Effects of ultrasound-guided lauromacrogol sclerotherapy on liver function and levels of Cor, AD,and NE in patients with hepatic cysts

HAO Dong¹, WANG Chen-xi², ZHANG Kun-jie³

1. Second Department of Surgery, Tanghe County Traditional Chinese Medicine Hospital, Henan 473400, China;
2. Fourth Department of General Surgery, Nanyang Medical College First Affiliated Hospital, Henan 473000, China;
3. First Department of General Surgery, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Received:2024-02-01 Online:2024-06-30 Published:2024-08-28

摘要/Abstract

摘要： 目的探讨超声引导下聚桂醇硬化治疗对肝囊肿患者肝功能及应激水平的影响。方法选择2020年1月—2023年3月我院收治的肝囊肿患者62例,随机分观察与对照组,各31例。对照组行超声引导下无水乙醇注射,观察组行超声引导下聚桂醇注射。评估两组临床疗效;术前及术后1周检测比较两组肝功能;术前及术后1 d检测比较两组应激指标及血常规[血小板计数(PLT)、白细胞计数(WBC)、血红蛋白(Hb)];记录两组并发症。结果两组总有效率组间比较差异无统计学意义(93.55 % vs 90.32 %,P>0.05)。术后1周,对照组丙氨酸氨基转移酶、天冬氨酸氨基转移酶显著上升(P<0.05),且显著高于观察组[(47.36±11.27)U/L vs(62.41±10.35)U/L、(38.06±5.62)U/L vs(72.85±21.96)U/L](P<0.05)。术后1 d,两组各应激指标显著上升(P<0.05),但观察组更低[(0.25±0.06)ng/mL vs(0.32±0.05)ng/mL、(277.16±24.79)ng/mL vs(317.42±30.15)ng/mL、(60.14±5.49)pg/mL vs(66.87±7.05)pg/mL](P<0.05)。术后1 d,两组PLT、Hb较治疗前无显著变化(P>0.05),对照组WBC显著上升(P<0.05),且对照组WBC显著高于观察组[(37.32±6.55)×10⁹/L vs(41.38±8.07)×10⁹/L](P<0.05)。观察组不良反应发生率更低(P<0.05)。结论聚桂醇在肝囊肿硬化治疗中疗效较佳,对肝功能、应激反应及炎症反应的影响小,且能够减少并发症发生,具有临床推广意义。

关键词: 肝囊肿, 超声引导, 聚桂醇, 硬化治疗, 应激

Abstract: Objective To evaluate the effects of ultrasound-guided lauromacrogol sclerotherapy on liver function and stress hormone levels in patients with hepatic cysts. Methods Sixty-two patients with hepatic cysts admitted to our hospital from January 2020 to March 2023 were randomly assigned to either the observation group or the control group, with 31 patients in each group. The control group received anhydrous ethanol injections under ultrasound guidance, while the observation group received lauromacrogol injections under ultrasound guidance. Clinical efficacy was evaluated in both groups. Liver function was assessed and compared between the groups before and one week after the procedure. Stress indices and routine blood parameters [platelet count (PLT), white blood cell count (WBC), hemoglobin (Hb)] were measured and compared before and one day after the procedure. Complications were also recorded in both groups. Results There was no significant difference in the total effective rate between the two groups (93.55% vs 90.32%, P>0.05). One week post-operation, alanine aminotransferase(ALT) and aspartate aminotransferase(AST) levels in the control group were significantly elevated (P<0.05), and were notably higher than those in the observation group [(47.36±11.27) U/L vs. (62.41±10.35) U/L and (38.06±5.62) U/L vs. (72.85±21.96) U/L, respectively] (P<0.05). One day post-operation, stress indices in both groups increased significantly (P<0.05), but were lower in the observation group [(0.25±0.06) ng/mL vs. (0.32±0.05) ng/mL, (277.16±24.79) ng/mL vs. (317.42±30.15) ng/mL, (60.14±5.49) pg/mL vs. (66.87±7.05) pg/mL] (P<0.05). PLT and Hb levels showed no significant changes compared to pre-treatment values in both groups (P>0.05), while WBC cout in the control group significantly increased (P<0.05) and was higher than in the observation group [(37.32±6.55) ×10⁹/L vs. (41.38±8.07) ×10⁹/L](P<0.05). The incidence of adverse reactions was lower in the observation group (P<0.05). Conclusion Lauromacrogol is effective in the treatment of hepatic cysts, demonstrating minimal impact on liver function, stress response, and inflammatory response, while also reducing the incidence of complications. These findings highlight its clinical significance.

Key words: Hepatic cyst, Ultrasonic guidance, Lauromacrogol, Sclerotherapy, stress

郝栋, 王晨曦, 张坤杰. 超声引导下聚桂醇硬化治疗对肝囊肿患者肝生化指标及Cor、AD、NE水平的影响[J]. 肝脏, 2024, 29(6): 714-718.

HAO Dong, WANG Chen-xi, ZHANG Kun-jie. Effects of ultrasound-guided lauromacrogol sclerotherapy on liver function and levels of Cor, AD,and NE in patients with hepatic cysts[J]. Chinese Hepatolgy, 2024, 29(6): 714-718.

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