铁死亡在肝脏疾病中的研究进展

摘要/Abstract

摘要： 铁死亡是近年来发现的一种非凋亡形式的程序性细胞死亡,并且在形态学、生物化学和遗传学上明显不同于凋亡、坏死和自噬,它主要是由胱氨酸耗竭和脂质活性氧(ROS)过量产生引发脂质过氧化所导致的。近期研究表明,铁死亡在肝脏疾病的进展中发挥重要作用,如何通过调节细胞铁死亡来干预肝脏疾病的发生和发展,已成为病因学研究和临床治疗的热点。本文根据近期的研究报道阐述铁死亡的调节机制,以及为未来治疗肝脏疾病提供新思路。

张小雅, 沈起艳, 石春霞, 龚作炯. 铁死亡在肝脏疾病中的研究进展[J]. 肝脏, 2024, 29(6): 739-742.

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