黄酮类化合物对对乙酰氨基酚诱导肝损伤的保护作用

摘要/Abstract

摘要： 对乙酰氨基酚(acetaminophen,APAP)也被称为扑热息痛,可用于治疗发热、疼痛和炎症。而过量服用对乙酰氨基酚会导致急性肝功能衰竭,甚至需要肝移植。目前临床治疗APAP导致的肝损伤是给予N-乙酰半胱氨酸(N-acetyl-L-cysteine,NAC),通过补充肝细胞内谷胱甘肽(glutathione,GSH)储存发挥保肝的作用。黄酮类化合物(flavonoids)是一类大量存在于食物和中药中的单体,可以通过恢复细胞的抗氧化防御系统、限制氧化应激、改善炎症、减轻坏死细胞死亡等来保护APAP诱导的肝毒性。本文针对黄酮类化合物减轻APAP引起肝毒性作用的分子机制和相关靶点的研究进展进行综述。

关键词: 对乙酰氨基酚, 肝损伤, 黄酮类化合物, 氧化应激, 炎症

张锦华, 张家祺, 张立超. 黄酮类化合物对对乙酰氨基酚诱导肝损伤的保护作用[J]. 肝脏, 2024, 29(5): 609-613.

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