系统免疫炎症指数在肝细胞癌TACE术后的临床意义

肝脏 ›› 2025, Vol. 30 ›› Issue (5): 633-637.

系统免疫炎症指数在肝细胞癌TACE术后的临床意义

谭舒丹, 王统华, 程吉云, 郭瑜修, 蓝常明, 余贤恩

533000 广西百色百色市人民医院消化内科一病区(谭舒丹,程吉云,蓝常明,余贤恩),儿科(郭瑜修);右江民族医学院附属医院消化内科(王统华)

收稿日期:2024-07-28 出版日期:2025-05-31 发布日期:2025-07-04
通讯作者: 王统华
基金资助:
2023年百色市科学研究与技术开发计划课题(20230579);2020年高层次人才科研项目人才专项(R202011703)

The clinical significance of preoperative systemic immunoinflammatory index in patients with hepatocellular carcinoma after transcatheter arterial chemoembolization

TAN Shu-dan¹, WANG Tong-hua², CHENG Ji-yun¹, GUO Yu-xiu³, LAN Chang-ming¹, YU Xian-en¹

1. Department of Gastroenterology, Baise People's Hospital, Guangxi 533000,China;
2. Department of Gastroenterology, Affiliated Hospital of Youjiang Ethnic Medical College, Guangxi 533000,China;
3. Department of Pediatrics, Baise People's Hospital, Guangxi 533000,China

Received:2024-07-28 Online:2025-05-31 Published:2025-07-04
Contact: WANG Tong-hua

摘要/Abstract

摘要： 目的分析系统免疫炎症指数(systemic immune-inflammation index,SII)对肝细胞癌(hepatocellular carcinoma,HCC)肝动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)术后的预后评估。方法纳入2017 年 1 月至2021 年 10 月在百色市人民医院收治的HCC患者127例,均接受 TACE 治疗。通过计算SII值,制作ROC曲线判断SII的预测价值。结果 SII评估HCC患者TACE术后预后的AUC为0.707,SII的最佳临界值为337.125,根据该临界值将患者分为高SII组(≥337.125)和低SII组(<337.125)。低SII组1年、2年生存率为67.4％、51.1％,高SII组1年、2年生存率为35.4％、20.2％,低SII组与高SII组的生存时间分别为36.0个月和9.0个月。结论 TACE术前SII高水平可能成为HCC不良预后的危险因素,SII低水平生存率高于高SII组。

关键词: 肝细胞癌, 肝动脉化疗栓塞, 系统免疫炎症指数, 生存分析

Abstract: Objective To investigate the role of preoperative systemic immune inflammation index (SII) in the prognosis of hepatocellular carcinoma (HCC) treated with transcatheter arterial chemoembolization (TACE). Methods The clinical data of 127 patients with HCC who underwent TACE in the Baise people’s hospital from January 2017 to October 2021 were analyzed retrospectively. We determine the predictive value of SII by calculating SII value and making receiver operating characteristic (ROC) curve. Results The area under curve (AUC) of SII calculated by ROC curve was 0.707, the corresponding optimal cut-off value was 337.125. With this value as the boundary, the SII was defined as low SII group and high SII group. The 1-year and 2-year survival rates of low SII group were 67.4% and 51.1%, while those in high SII group were 35.4% and 20.2%. The median values of low SII group and high SII group were 36.0 months and 9.0 months, respectively. The survival rate of low SII group revealed a better prognosis. Conclusion A higher level of SII before surgery may be a risk factor for poor prognosis of HCC, and the survival rate of patients with lower SII level is better than those of patients with higher SII level.

Key words: Hepatocellular carcinoma, Survival analysis, Hepatic artery chemoembolization, Systemic immune inflammatory index

谭舒丹, 王统华, 程吉云, 郭瑜修, 蓝常明, 余贤恩. 系统免疫炎症指数在肝细胞癌TACE术后的临床意义[J]. 肝脏, 2025, 30(5): 633-637.

TAN Shu-dan, WANG Tong-hua, CHENG Ji-yun, GUO Yu-xiu, LAN Chang-ming, YU Xian-en. The clinical significance of preoperative systemic immunoinflammatory index in patients with hepatocellular carcinoma after transcatheter arterial chemoembolization[J]. Chinese Hepatolgy, 2025, 30(5): 633-637.

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