1型固有淋巴样细胞在急性肝损伤中的机制研究进展

摘要/Abstract

摘要： 急性肝损伤(ALI)起病急骤,部分患者病情进展迅速,可进展为急性肝衰竭,病死率高,已成为全球重要的公共卫生问题。肝脏固有免疫细胞在ALI发生、发展及损伤修复中发挥关键作用。1型固有淋巴样细胞(ILC1)是高度富集于肝脏的固有免疫细胞亚群,兼具固有免疫应答的快速性与适应性免疫应答的特异性,在肝脏免疫稳态维持中具有重要地位,在近几年的研究中备受关注。ILC1在ALI中的功能呈现双重性,一方面通过调控炎症反应、参与坏死细胞清除及促进组织再生以维护肝脏稳态;另一方面在特定病理条件下亦可能放大炎症,加重肝功能损害。深入解析ILC1的生物学特征以及其在不同ALI中的作用,有助于深化对ALI免疫机制的理解,并为识别关键调控点、发现新的诊断标志物与治疗靶点提供重要依据。

关键词: 1型固有淋巴样细胞, 急性肝损伤, 肝衰竭, 免疫调控

蒋晶晶, 娄薇薇, 李青, 谢青, 赖荣陶. 1型固有淋巴样细胞在急性肝损伤中的机制研究进展[J]. 肝脏, 2025, 30(12): 1598-1601.

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