肝动脉灌注化疗栓塞术联合卡瑞利珠单抗对原发性肝癌患者免疫功能和肿瘤标志物的影响

摘要/Abstract

摘要： 目的原发性肝癌治疗中卡瑞利珠单抗联合TACE的疗效分析。方法研究样本为2020年1月~2022年1月在神木市医院接受治疗的原发性肝癌患者,共96例,随机分为对照组与观察组,每组48名患者。给予所有患者TACE,观察组在此基础上联合静脉滴注卡瑞利珠单抗,均治疗3个月。评估两组治疗3个月后的临床疗效,比较两组治疗前后的免疫指标、PD-1、血管内皮生长因子(VEGF)、肿瘤标志物、肝功能。比较患者2年中的疾病无进展期(PFS)和生存率。结果观察组和对照组的的治疗总有效率分别为78.17%(38/48)和54.17%(26/48),观察组高于对照组(P＜0.05);治疗3个月后,观察组CD3⁺、CD4⁺、CD4⁺/CD8⁺分别为(47.21±5.23)%、(34.71±4.04)%和(2.11±0.42),且观察组治疗后的CD8⁺、PD-1、VEGF、肝功能指标和肿瘤标志物水平比对照组下降。对照组PFS和生存率为(10.44±2.01)月和54.17%(26/48),观察组为(15.83±2.69)月和79.17%(38/48),差异均有统计学意义(P＜0.05)。结论卡瑞利珠单抗结合TACE能提高原发性肝癌治疗效果。

关键词: 肝动脉灌注化疗栓塞术, 卡瑞利珠单抗, 原发性肝癌, 免疫功能, 肿瘤标志物

Abstract: Objective To explore the effectiveness of combining transarterial chemoembolization (TACE) with camrelizumab in treating primary liver cancer. Methods Ninety-six individuals with primary liver cancer treated in Shenmu City Hospital from January 2020 to January 2022 were randomly assigned into treatment group and control group. Two groups underwent TACE, and the observation group additionally received Camrelizumab for three months. The clinical efficacy was evaluated and the immune function, tumor marker levels, liver function, and serum levels of PD-1and VEGF were compared after three months of treatment. Progression-free survival (PFS) and survival rates over a 2-year follow-up period were also compared. Results The overall effective treatment rate for the treatment group was 78.17% (38/48), which was greater than the 54.17% (26 out of 48) in the control group. Following three months of therapy, the levels of CD3⁺, CD4⁺, and CD4⁺/CD8⁺ ratios in the treatment group were (47.21±5.23)%, (34.71±4.04)%, and (2.11±0.42) respectively, and the levels of CD8⁺, tumor markers, liver function indicators, PD-1, and VEGF were reduced in the treatment group compared to the control group, all showing statistical significance (all P<0.05). PFS in 2-year and survival rates of the treatment group were (15.83±2.69) months and 79.17% (38/48) respectively, compared to (10.44±2.01) months and 54.17% (26/48) in the control group, with significant statistical differences observed (P<0.05). Conclusion TACE combined with Camrelizumab enhances immune function and reduces tumor marker levels in patients with primary liver cancer.

Key words: Transarterial chemoembolization, Camrelizumab, Primary liver cancer, Immune function, Tumor markers

刘美强, 高永江. 肝动脉灌注化疗栓塞术联合卡瑞利珠单抗对原发性肝癌患者免疫功能和肿瘤标志物的影响[J]. 肝脏, 2025, 30(12): 1652-1655.

LIU Mei-qiang, GAO Yong-jiang. Effect of transarterial chemoembolization combined with camrelizumab on immune function and tumor markers in patients with primary liver cancer[J]. Chinese Hepatolgy, 2025, 30(12): 1652-1655.

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