午睡与非酒精性脂肪性肝病关系的孟德尔随机化分析

摘要/Abstract

摘要： 目的运用两样本孟德尔随机化分析方法,探讨午睡与非酒精性脂肪性肝病风险的因果关系。方法从IEU Open GWAS数据库中获取午睡与非酒精性脂肪性肝病的数据集。运用逆方差加权法、MR-Egger法和加权中位数法探讨午睡与非酒精性脂肪性肝病因果关系,并运用Cochran′s Q检验、MR-Egger回归、MR-PRESSO、Leave one out、漏斗图和森林图法等方法评价研究结果的稳定性和可靠性。结果三种方法得到的因果效应方向一致,逆方差加权法具有统计学意义:OR=2.166,95%CI=1.274~3.684,P=0.004。WME分析结果:OR=1.643,95%CI=0.758~3.564,P=0.209。MR-Egger回归结果显示:OR=4.201,95%CI=0.591~29.863,P=0.155;IVW检验:Q=105.474,P=0.217;MR-Egger检验:Q=104.946,P=0.207,结果未发现差异具有统计学意义。MR-PRESSO分析(P=0.246)和MR-Egger回归分析(P=0.493)不支持水平多效性的存在,研究结果稳健。结论本研究从遗传学的角度,初步揭示午睡与非酒精性脂肪性肝病风险具有正相关的因果关系。

关键词: 午睡, 非酒精性脂肪性肝病, 孟德尔随机化

Abstract: Objective To explore the causal relationship between daytime nap and the risk of non-alcoholic fatty liver disease by using two sample Mendelian randomization analysis. Methods Dataset of daytime nap and non-alcoholic fatty liver disease were obtained from the IEU Open GWAS database. Using the inverse variance weighting, MR Egger, and weighted median methods to explore the causal relationship between daytime nap and non-alcoholic fatty liver disease, and using Cochran's Q test, MR Egger regression, MR-PRESSO, Leave one out, funnel plot, and forest plot methods to evaluate the stability and reliability of the research results. Results The causal effects obtained by the three methods were consistent, and the inverse variance weighting method had statistical significance (OR=2.166, 95% CI=1.274~3.684, P=0.004). The results of WME analysis (OR=1.643, 95%CI=0.758~3.564, P=0.209). MR-Egger regression showed (OR=4.201, 95%CI=0.591~29.863, P=0.155). IVW test (Q=105.474, P=0.217) and MR-Egger test (Q=104.946, P=0.207) results did not show significant heterogeneity. MR-PRESSO analysis (P=0.246) and MR-Egger regression analysis (P=0.493) did not support the presence of horizontal pleiotropy, and the findings were robust. Conclusion From a genetic perspective, this study preliminarily revealed a positive causal relationship between nap time and the risk of non-alcoholic fatty liver disease.

Key words: Daytime nap, Nonalcoholic fatty liver disease, Mendelian randomization

王继才, 张广权, 吴芬芳, 史宪杰. 午睡与非酒精性脂肪性肝病关系的孟德尔随机化分析[J]. 肝脏, 2025, 30(12): 1695-1699.

WANG Ji-cai, ZHANG Guang-quan, WU Fen-fang, SHI Xian-jie. The causal relationship between daytime nap and non-alcoholic fatty liver disease: a two-sample mendelian randomization analysis[J]. Chinese Hepatolgy, 2025, 30(12): 1695-1699.

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