关键词: 原发性肝癌, γ-谷氨酰转移酶, 丙氨酸氨基转移酶, 中性粒细胞与淋巴细胞比值, 介入治疗, 预后

Abstract: Objective To investigate the prognostic value of the preoperative γ-glutamyl transpeptidase/alanine aminotransferase (GGT/ALT) ratio and inflammatory markers in patients with primary hepatocellular carcinoma (HCC) undergoing interventional therapy and to analyze the prognosis associated risk factors. Methods A retrospective analysis was conducted on the clinical data of 116 patients with primary HCC who underwent interventional therapy in our hospital from August 2022 to December 2023. Based on prognosis, patients were categorized into a good prognosis group (n=73) and a poor prognosis group (n=43). Preoperative GGT/ALT ratio, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP) levels were collected and analyzed. Univariate and multivariate logistic regression analyses were performed to identify the independent prognosis associated risk factors. Results The preoperative GGT/ALT ratio (3.75±1.24 vs. 2.31±0.86), NLR(3.86±1.35 vs. 2.43±0.92), PLR(168.3±42.6 vs. 126.5±35.7), and CRP levels (15.64±5.27 vs. 8.32±3.15 mg/L) were significantly higher in the poor prognosis group compared to those of the good prognosis group (P<0.05). Univariate analysis indicated that tumor size, tumor number, Child-Pugh classification, GGT/ALT ratio, NLR, PLR, and CRP were factors associated with poor prognosis (P<0.05). Multivariate logistic regression analysis identified the GGT/ALT ratio (OR=2.657, 95% CI: 1.542~4.576, P=0.001), NLR (OR=1.986, 95% CI: 1.234~3.198, P=0.005), and Child-Pugh classification (OR=2.143, 95% CI: 1.326~3.465, P=0.002) as independent prognosis associated risk factors for interventional therapy in primary HCC patients. Conclusion The preoperative GGT/ALT ratio and NLR can serve as important prognostic indicators for patients with primary HCC undergoing interventional therapy. Combined with Child-Pugh classification, these parameters may provide valuable reference points for clinical treatment planning and prognosis evaluation.

Key words: Primary hepatocellular carcinoma, γ-glutamyl transpeptidase, Alanine aminotransferase, Neutrophil-to-lymphocyte ratio, Interventional therapy, Prognosis