[1] Wooddell CI, Yuen MF, Chan HL, et al. RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg. Sci Transl Med, 2017, 9: eaan0241. [2] Chen EQ, Feng S, Wang ML, et al. Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B. Sci Rep, 2017, 7: 173. [3] Wang J, Shen T, Huang X, et al. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. J Hepatol, 2016:700-710. [4] Caviglia GP, Abate ML, Tandoi F, et al. Quantitation of HBV cccDNA in anti-HBc-positive liver donors by droplet digital PCR: a new tool to detect occult infection. J Hepatol, 2018. [5] Zhang X, Lu W, Zheng Y, et al. In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection. J Clin Invest, 2016, 126: 1079-1092. [6] Mason WS, Gill US, Litwin S, et al. HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant. Gastroenterology, 2016, 151: 986-998 e984. [7] 鲁凤民, 王芸. 血清高尔基体糖蛋白73在硬化诊断中的应用及其相关机制. 中华肝脏病杂志, 2018, 26: 321-324. [8] Chan HL, Wong GL, Choi PC, et al. Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B. J Viral Hepat, 2009, 16: 36-44. [9] Kim KM, Choi WB, Park SH, et al. Diagnosis of hepatic steatosis and fibrosis by transient elastography in asymptomatic healthy individuals: a prospective study of living related potential liver donors. J Gastroenterol, 2007, 42: 382-388. [10] Nguyen LH, Chao D, Lim JK, et al. Histologic changes in liver tissue from patients with chronic hepatitis B and minimal increases in levels of alanine aminotransferase: a meta-analysis and systematic review. Clin Gastroenterol Hepatol, 2014, 12: 1262-1266. [11] Gill US, Pallett LJ, Kennedy PTF, et al. Liver sampling: a vital window into HBV pathogenesis on the path to functional cure. Gut, 2018, 67: gutjnl-2017-314873. |