老年人群酒精性肝硬化合并2型糖尿病的相关危险因素分析

摘要/Abstract

摘要： 目的本研究旨在确定酒精性肝硬化(ALC)老年患者发生2型糖尿病(T2DM)相关的危险因素。方法回顾性分析2011年1月至2016年12月在我院消化内科治疗的1783例ALC患者的临床资料。将其中207例ALC合并T2DM患者作为观察组;207例年龄相符的ALC非T2DM患者作为对照组。采集每位受试者的人口学资料、人体测量学数据、生活习惯以及临床和实验室数据。结果两组患者的一般临床特征比较,在教育水平,吸烟史,高血压,ALC持续时间,ALC家族史以及T2DM家族史存在明显差异(P<0.05)。两组患者的实验室检查数据比较,γ-谷氨酰转肽酶(γ-GT)、肌酐(CREA)、甘油三酯(TG)、高密度脂蛋白(HDL)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)以及空腹血浆胰岛素(FPI)差异有明显统计学意义(P<0.05)。多变量分析结果显示,ALC病程长(≥15年)、T2DM家族史、受教育程度低、高TG水平、高γ-GT水平是ALC患者发生T2DM的独立风险因素。结论临床上对于具有ALC病程长、T2DM家族史、受教育程度低、TG水平高、γ-GT水平高等危险因素的ALC患者应该加强检测血糖水平,并积极控制TG、γ-GT水平。

关键词: 酒精性肝硬化, 2型糖尿病, 甘油三酯, γ-谷氨酰转肽酶

张帆, 崔海梦, 罗庆锋. 老年人群酒精性肝硬化合并2型糖尿病的相关危险因素分析[J]. 肝脏, 2018, 23(7): 625-628.

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