血清chemerin水平与2型糖尿病、非酒精性脂肪性肝病的关系

肝脏 ›› 2018, Vol. 23 ›› Issue (3): 239-241.

血清chemerin水平与2型糖尿病、非酒精性脂肪性肝病的关系

闫丽丽, 吕骥, 贾红玉, 姜东春

066000 河北秦皇岛市第一医院内科

收稿日期:2017-05-25 发布日期:2020-04-30

Received:2017-05-25 Published:2020-04-30

摘要/Abstract

摘要： 目的探讨血清chemerin水平与2型糖尿病、非酒精性脂肪性肝病的关系。方法收集河北秦皇岛地区汉族人群170例受试对象,其中单纯2型糖尿病(T2DM)患者60例、2型糖尿病合并非酒精性脂肪性肝病(T2DM+NAFLD)患者50例和健康人群60名,采用ELISA法检测上述人群血清chemerin水平。结果 (1)空腹血清chemerin水平在T2DM患者和T2DM+NAFLD患者均比健康人群显著增高(P<0.01),T2DM+NAFLD患者增高最为明显;(2)以T2DM为二分类应变量与健康人群相比,血清chemerin水平、胰岛素抵抗指数(LnHOMA-IR)及HbA1c(OR>1)进入方程;(3)以T2DM是否伴发NAFLD为二分类应变量,血清chemerin水平(OR>1)进入方程。结论 chemerin可能是T2DM、NAFLD发病的危险因子之一,可能促进T2DM合并NAFLD的发生。

闫丽丽, 吕骥, 贾红玉, 姜东春. 血清chemerin水平与2型糖尿病、非酒精性脂肪性肝病的关系[J]. 肝脏, 2018, 23(3): 239-241.

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