Abstract: Objective To investigate the indocyanine green clearance test for preoperative liver reserve function of patients with primary liver cancer.Methods Fifty healthy people and 71 patients were enrolled as control group and study group,respectively.Indocyanine green clearance rate in 15 minutes（ICGR15）,hepatic function,blood routine test and abdominal ultrasound were measured in all patients,and the Child-Turcotte-Pugh （CTP）scores were calculated for classification.All data were analyzed by student＇s t-test,one-way analysis of variance and linear correlation analysis with SPSS 17.0.Results The levels of ICGR15 in patients with primary liver cancer（18.7±4.3）were higher than those in controls（4.7±1.2）（t=–22.39,P<0.05）.Moreover,levels of ICGR15 were positively correlated with the CTP score（r=0.722,P<0.05）,but negatively correlated with hepatic blood flow（r=–0.889,P<0.05）and plasma clearance rate（r=–0.753,P<0.05）.Comparisons in levels of prothrombin time（PT）,international normalized ratio（INR）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,albumin（Alb）and total bilirubin（TBil）among patients with different levels of ICGR15 showed statistically differences（t=3.39,61.9,2.62,3.19,69.0,40.5;P<0.05）.Meanwhile,levels of ICGR15 was positively correlated with the levels of PT,INR,AST and TBil（r=0.665,0.527,0.316,0.721;P<0.05）,but negatively correlated with the levels of Alb（r=–0.507,P<0.05）.Furthermore,ICGR15 showed strongest correlation with the levels of PLT and TBil.Conclusion The indocyanine green clearance test could dynamically reflect liver reserve function,which is more accurately than CTP classification.

Key words: Primary liver cancer, Indocyanine green clearance test, Liver reserve function